Anti-LUC7L2 Antibody, Rabbit Polyclonal sinobiological 205888-T02

$143.00
In stock
SKU
205888-T02
Catalog No.SizePrice (USD)
205888-T02-5050 µL$147.96
205888-T02-100100 µL$251.64
205888-T02-200200 µL$355.32

General Information

Product nameAnti-LUC7L2 Antibody, Rabbit Polyclonal
Validated applicationsICC/IF (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman LUC7L2
ImmunogenE. coli-derived Human LUC7L2 fragment
PreparationProduced in rabbits immunized with E. coli-derived Human LUC7L2 fragment, and purified by antigen affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A & Antigen Affinity
FormulationPBS, pH7.0 with 0.03% Proclin300
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-CGI-59 Antibody; Anti-CGI-74 Antibody; Anti-FLJ10657 Antibody; Anti-hLuc7B2 Antibody; Anti-H_NH0792N18.3 Antibody; Anti-LUC7B2 Antibody

Image / Experimental Information

Image 1 DescriptionImmunofluorescence staining of LUC7L2 in MCF7 cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-Human LUC7L2 polyclonal antibody (dilution ratio 1:200) at 4℃ overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to Nucleus.
Image 1 Alt TextHuman LUC7L2 Immunofluorescence(IF) 26607
Image 1 URLSource image

Background Information

DescriptionLUC7L2 (also known as CGI-59, CGI-74 and LUC7B2) resides on chromosome of 7q34. Indeed, chromosome 7 represents one of the most frequently altered chromosomes in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), with a variety of deletions and translocations described. LUC7L2 protein contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. LUC7L2 transcripts are widely distributed in mammalian tissues, and undergo alternative splicing and polyadenylation. LUC7L2 is also co-localized with U1-70K and may function with SCNM1 in recognition of weak splice donor sites.
References
  1. Singh H, et al. (2013) Putative rna-splicing gene luc7l2 on 7q34 represents a candidate gene in pathogenesis of myeloid malignancies. Blood Cancer J 3 (5): e117.
  2. Howell VM, et al. (2007) Evidence for a direct role of the disease modifier scnm1 in splicing. Hum Mol Genet 16 (20): 2506-2516.

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