Produced in rabbits immunized with E. coli-derived Human METTL9 fragment, and purified by antigen affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
PBS, pH7.0 with 0.03% Proclin300
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.
Human methytransferase like proteins (METTL) are part of a large protein family characterized by the presence of binding domains for S-adenosyl methionine, a co-substrate for methylation reactions. Members of the METTL family have been shown to methylate RNA in mammals: METTL3 and METTL14 catalyze the formation of m6A (N6-methyladenosine) in mRNA as well as in primary-microRNAs. Many of the METTL proteins appear to function outside of stable complexes whereas others including METTL7B, METTL8 and METTL9 have high-confidence interaction partners.
References
Ignatova VV, et al. (2019) The interactome of a family of potential methyltransferases in hela cells. Sci Rep 9 (1): 6584.