Anti-MIF Antibody, Rabbit Polyclonal sinobiological 50066-T36
$243.00
In stock
SKU
50066-T36
| Catalog No. | Size | Price (USD) |
| 50066-T36-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-MIF Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), IP (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse MIF |
| Immunogen | Recombinant Mouse MIF Protein (Catalog#50066-M08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse MIF (rM MIF; Catalog#50066-M08H; P34884; Pro2-Ala115). MIF specific IgG was purified by Mouse MIF affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-DER6 Antibody; Anti-GIF Antibody; Anti-Glif Antibody; Anti-Mif Antibody
Image / Experimental Information
| Image 1 Description | Anti-MIF rabbit polyclonal antibody at 1:500 dilution Lane A: RAW246.7 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:12 kDa Observed band size:12 kDa |
| Image 1 Alt Text | Mouse MIF Western blot (WB) 40522 |
| Image 1 URL | Source image |
| Image 2 Description | Anti-MIF rabbit polyclonal antibody at 1:500 dilution Lane A: RAW246.7 Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:12 kDa Observed band size:12 kDa |
| Image 2 Alt Text | Mouse MIF Immunoprecipitation(IP) 40523 |
| Image 2 URL | Source image |
Background Information
| Full Name | macrophage migration inhibitory factor (glycosylation-inhibiting factor) |
| Description | Macrophage migration inhibitory factor (MIF) is an immunoregulatory cytokine, the effect of which on arresting random immune cell movement was recognized several decades ago. Despite its historic name, MIF also has a direct chemokine-like function and promotes cell recruitment. MIF is a ubiquitously expressed protein that plays a crucial role in many inflammatory and autoimmune disorders. Increasing evidence suggests that MIF also controls metabolic and inflammatory processes underlying the development of metabolic pathologies associated with obesity. Further research has shown that MIF plays a particularly critical part in cell cycle regulation and therefore in tumorigenesis as well. The significance of the role of MIF in a variety of both solid and hematologic tumors has been established. More recently, interest has increased in the role of MIF in the development of the central nervous system (CNS) tumors, in which it appears to influence cell cycle control. MIF contributes to malignant disease progression on several different levels. Both circulating and intracellular MIF protein levels are elevated in cancer patients and MIF expression reportedly correlates with stage, metastatic spread, and disease-free survival. Blockade of MIF bioactivity successfully inhibited tumor cell growth in vivo and in vitro. MIF plays important role in the pathogenesis of gastrointestinal, hepatic, and pancreatic disorders. |
| References |
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