| Catalog No. | Size | Price (USD) |
| 50006-RP01-100 | 100 µL | $147.96 |
| 50006-RP01-200 | 200 µL | $251.64 |
| 50006-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-ASAH2 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse ASAH2 |
| Immunogen | Recombinant Mouse ASAH2 protein (Catalog#50006-M07H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse ASAH2 Lumenal domain (rM ASAH2; Catalog#50006-M07H; Thr 34-Thr 756; NP_061300.1). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-Asah2 Antibody
Background Information
| Full Name | N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 |
| Description | ASAH2 (N-acylsphingosine amidohydrolase 2), also known as neutral ceramidase, is a type II integral membrane protein that can be cleaved to produce a soluble secreted protein. The enzyme is abundant in the brush border membranes of the intestine, and also expressed in several tissues such as kidney, brain and liver. The primary structure of ASAH2/neutral ceramidase is highly conserved from bacteria to humans, however, there is a clear difference in the molecular architecture. The murine ASAH2 possesses ‘amucin box’, a Ser/Thr/Pro-rich domain glycosylated with O-glycans which is necessary to retain the enzyme on the plasma membrane as a type II integral protein. The major physiological function of ASAH2/neutral ceramidase is the metabolism of dietary sphingolipids, and thus plays a role in the generation of messenger molecules such as sphingosine and sphingosine 1-phosphate. |
| References |
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