| Catalog No. | Size | Price (USD) |
| 206326-T08-50 | 50 µL | $147.96 |
| 206326-T08-100 | 100 µL | $251.64 |
| 206326-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-CCDC8 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CCDC8 |
| Immunogen | E. coli-derived Human CCDC8 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human CCDC8 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-3M3 Antibody; Anti-DKFZp564K0322 Antibody; Anti-p90 Antibody; Anti-PPP1R20 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human CCDC8 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human CCDC8 Immunohistochemistry(IHC) 26418 |
| Image 1 URL | Source image |
Background Information
| Description | Coiled-coil domain-containing protein 8 (CCDC8) is a tumor suppressor in several types of cancer, such as breast and prostate cancers. CCDC8 may suppress the invasion and metastasis of lung cancer cells, and it may represent a promising therapeutic target for non-small cell lung cancer. The CCDC8 gene is mutated in 3M syndrome, a short-stature disorder with additional facial and skeletal abnormalities. Two other genes mutated in this syndrome encode CUL7 and OBSL1. CUL7, OBSL1, and CCDC8 are members of a pathway controlling mammalian growth. CCDC8 can strongly inhibit HIV-1 production. CCDC8 is a membrane-associated protein, and N-terminal of CCDC8 is very important for membrane binding, and also important for inhibition of Gag assembly. C-terminal deletion of CCDC8 has a little effect on anti-HIV-1 effect. Overexpression of CCDC8 can cause newly assembled HIV-1 Gag particles on the plasma membrane to be endocytosed and degraded in lysosome. |
| References |
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