| Catalog No. | Size | Price (USD) |
| 10900-MM05-1 | 1 mL | $1,377.43 |
| 10900-MM05-20 | 20 µL | $88.87 |
| 10900-MM05-50 | 50 µL | $147.96 |
| 10900-MM05-100 | 100 µL | $251.64 |
| 10900-MM05-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-CCL5/RANTES Antibody, Mouse Monoclonal |
| Validated applications | ELISA(Det) (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CCL5/RANTES |
| Immunogen | Recombinant Human CCL5 Protein (Catalog#10900-HNAE) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CCL5 (rh CCL5; Catalog#10900-HNAE; NP_002976.2; Ser24-Ser91). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Source | Monoclonal Mouse IgG1 Clone #05 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-D17S136E Antibody; Anti-eoCP Antibody; Anti-MGC17164 Antibody; Anti-RANTES Antibody; Anti-SCYA5 Antibody; Anti-SIS-delta Antibody; Anti-SISd Antibody; Anti-TCP228 Antibody
Background Information
| Full Name | chemokine (C-C motif) ligand 5 |
| Description | Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokin ligand 5(CCL5) is chemotactic for T cells, basophils and eosinophils. Chemokin ligand 5(CCL5) has been considered a HIV-supressor secreted by CD8 T cells and other immune cells. Chemokin ligand 5(CCL5) is a key to activating recruit leukocytes into inflammatory sites and in the presence of particular cytokines released by T cells, it can change the NK cells into CHAK cells. |
| Research Areas |
|
| Tags |
|
| References |
|
title: CD147-K148me2-Driven Tumor Cell-Macrophage Crosstalk Provokes NSCLC Immunosuppression via the CCL5/CCR5 Axis.
authors: Ke Wang; Xiaohong Chen; ...; Liang Chen
journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
date: 2024-06-14
pmid: 38873823
cited_by_count: 12
techniques: Binding Assay; Cell Culture; Chemotaxis Assay; Control; Expressing; Flow Cytometry; Immunohistochemistry; In Vivo; Knockdown; Luciferase; Methylation; Microscopy; Migration; Plasmid Preparation; Pore Size; Protein Extraction; RNA Sequencing; Recombinant; Reporter Assay; Reverse Transcription Polymerase Chain Reaction; Sequencing; Staining; Western Blot
bioz_score: 92
