Anti-CCR3 Antibody, Rabbit Polyclonal sinobiological 100451-T34
$243.00
In stock
SKU
100451-T34
| Catalog No. | Size | Price (USD) |
| 100451-T34-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-CCR3 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CCR3 |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Human CCR3 |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the C-terminus of the Human CCR3, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-C C CKR3 Antibody; Anti-CC-CKR-3 Antibody; Anti-CD193 Antibody; Anti-CKR 3 Antibody; Anti-CKR3 Antibody; Anti-CMKBR3 Antibody
Image / Experimental Information
| Image 1 Description | Immunofluorescence staining of CCR3 in HEK293 cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-Human CCR3 polyclonal antibody (dilution ratio 1:100) at 4℃ overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue).Positive staining was localized to Cytoplasm and Cell membrane. |
| Image 1 Alt Text | Human CCR3 Immunofluorescence(IF) 36892 |
| Image 1 URL | Source image |
| Image 2 Description | Immunofluorescence staining of CCR3 in HEK293 cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS,blocked with 10% serum, and incubated with rabbit anti-Human CCR3 polyclonal antibody (dilution ratio 1:100) at 4℃ overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue).Positive staining was localized to Cytoplasm and Cell membrane. |
| Image 2 Alt Text | Human CCR3 Western blot (WB) 36891 |
| Image 2 URL | Source image |
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Background Information
| Full Name | chemokine (C-C motif) receptor 3 |
| Description | Tumors formed by lung adenocarcinoma cells with high expression of CCL28 grew faster and had a higher vascular density, whereas tumor formation rate of lung adenocarcinoma cells with CCL28 expression knockdown was quite low and had a lower vascular density. CCR3, receptor of CCL28, was highly expressed in vascular endothelial cells in lung adenocarcinoma when examining by immunohistochemistry. CCL28, as a chemokine induced by tumor hypoxia, could promote angiogenesis in lung adenocarcinoma through targeting CCR3 on microvascular endothelial cells. CCL28-CCR3 interactions are involved in the homeostatic trafficking of CD4(+) T cells to the upper airways. |
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