| Catalog No. | Size | Price (USD) |
| 50110-R012-F-25 | 25 Tests | $103.68 |
| 50110-R012-F-100 | 100 Tests | $133.30 |
General Information
| Product name | Recombinant Anti-CD27/TNFRSF7 Antibody (FITC), Rabbit Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse CD27/TNFRSF7 |
| Immunogen | Recombinant Mouse CD27 protein (Catalog#50110-M08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD27 / TNFRSF7 (rM CD27 / TNFRSF7; Catalog#50110-M08H; NP_001028298.1; Met 1-Arg 182) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| Source | Monoclonal Rabbit IgG Clone #012 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Concentration | 10 μl/Test, 0.1 mg/ml |
| Conjugate | FITC |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
Synonyms: Anti-Cd27 Antibody; Anti-S152 Antibody; Anti-Tnfrsf7 Antibody; Anti-Tp55 Antibody
Image / Experimental Information
| Image 1 Description | Expression of CD27 on mouse splenocytes. BABL/c splenocytes were stained simultaneously with FITC-conjugated mAb R012 and PE-conjugated anti-mouse CD3 mAb (BD Pharmingen™Cat. No. 553064). |
| Image 1 Alt Text | Mouse CD27/TNFRSF7 Flow Cytometry (FC) 5446 |
| Image 1 URL | Source image |
Background Information
| Full Name | CD27 molecule |
| Description | CD27, also known as TNFRSF7, is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage, and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a type I transmembrane glycoprotein of about 55 kDa existing as disulfide-linked homodimer, CD27 has been shown to play roles in lymphoid proliferation, differentiation, and apoptosis.It has an important role in the generation of T cell immunity and is an robust marker for normal memory B cells. It is a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B-cell differentiation, activation and immunoglobulin synthesis. |
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