| Catalog No. | Size | Price (USD) |
| 10051-R422-50 | 50 µL | $177.58 |
| 10051-R422-100 | 100 µL | $340.51 |
General Information
| Product name | Recombinant Anti-CD13 Antibody, Rabbit Monoclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CD13 |
| Immunogen | Recombinant Human CD13/ANPEP Protein (Catalog#10051-H08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human CD13/ANPEP (rh CD13/ANPEP; Catalog#10051-H08H; NP_001141.2; Lys69-Lys967,603Met/Ile). |
| Source | Monoclonal Rabbit IgG Clone #422 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-AP-M Antibody; Anti-AP-N Antibody; Anti-APN Antibody; Anti-CD13 Antibody; Anti-GP150 Antibody; Anti-hAPN Antibody; Anti-LAP1 Antibody; Anti-P150 Antibody; Anti-PEPN Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human ANPEP in human kidney with rabbit monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human CD13 Immunohistochemistry(IHC) 22829 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human ANPEP in human kidney with rabbit monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human CD13 Immunohistochemistry(IHC) 22830 |
| Image 2 URL | Source image |
Background Information
| Full Name | alanyl (membrane) aminopeptidase |
| Description | Aminopeptidase N (ANPEP or APN), also known as CD13, is a cell-surface metalloprotease located in the small-intestinal and renal microvillar membrane, as well as other plasma membranes. It belongs to the peptidase M1 family. CD13 plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases and is involved in the metabolism of regulatory peptides by diverse cell types. CD13/APN is a potent regulator of angiogenesis which is essential for tumor invasion and metastasis, and its transcription in activated endothelial cells is induced by angiogenic growth factors via the RAS/MAPK pathway. In addition, this enzyme has been shown to participate in antigen processing and presentation, and accordingly, defects in this gene appear to be a cause of various types of leukemia or lymphoma and carcinomas. |
| References |
|
title: Discovery of an Enzyme-Activated Fluorogenic Probe for In Vivo Profiling of Acylaminoacyl-Peptide Hydrolase.
authors: Shi-Yu Liu; Huiling Wang; ...; Le-Yu Huang
journal: Analytical Chemistry
date: 2025-02-04
pmid: 39862163
doi: 10.1021/acs.analchem.4c05192
cited_by_count: 1
techniques: Activation Assay; Activity Assay; Cell Culture; Clone Assay; Plasmid Preparation; Purification
bioz_score: 93
