Recombinant Mouse CD5L protein (Catalog#50020-M08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD5L / Aim (rM CD5L; Catalog#50020-M08H; Met 1-Val 352; NP_033820.2) .
Source
Monoclonal Rabbit IgG Clone #38
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
CD5L, also known as CD5 antigen-like, is a soluble protein belonging to group B of the scavenger receptor cysteine-rich (SRCR) superfamily and contains three SRCR domains. It is a secreted glycoprotein and expressed by macrophages presentin lymphoid tissues (spleen, lymph node, thymus, and bone marrow). It binds to myelomonocytic and lymphoid cells and may play an important role in the regulation of the innate and adaptive immune systems. CD5L functions as a pattern recognition molecule by binding both lipoteichoic acid (LTA) on Gram positive and lipopolysaccharide (LPS) on Gram negative bacteria. and the SRCR domain 1 of CD5L retains both the LPS and LTA binding activities. In addtion, it is revealed that CD5L seems to play a role as an inhibitor of apoptosis.
References
Resnick, D. et al., 1994, Trends Biochem. Sci. 19: 5-8.
Gebe, J. A. et al., 1997, J. Biol. Chem. 272 (10): 6151–6158.
Sarrias, M.R. et al., 2004, Crit. Rev. Immunol. 24: 1-37.
Mukhopadhyay, S. and Gordon, S., 2004, Immunobiology 209: 39-49.
Sarrias, M. R. et al.,2005, J. Biol. Chem. 280 (42): 35391–35398.