| Catalog No. | Size | Price (USD) |
| 50794-R241-P-25 | 25 Tests | $103.68 |
| 50794-R241-P-100 | 100 Tests | $222.17 |
General Information
| Product name | Recombinant Anti-CD146/MCAM Antibody (PE), Rabbit Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse CD146/MCAM |
| Immunogen | Recombinant Mouse CD146/MCAM Protein (Catalog#50794-M08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD146/MCAM (rM CD146/MCAM; Catalog#50794-M08H; Q8R2Y2-1; Met1-Val563) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Source | Monoclonal Rabbit IgG Clone #241 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Concentration | 5 μl/Test, 0.1 mg/ml |
| Conjugate | PE |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! |
Synonyms: Anti-1-gicerin Antibody; Anti-CD146 Antibody; Anti-CD149 Antibody; Anti-Mcam Antibody; Anti-Muc18 Antibody; Anti-s-endo Antibody; Anti-s-gicerin Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of Mouse MCAM(CD146) expression on BABL/c splenocytes. Cells were stained with PE-conjugated anti-Mouse MCAM(CD146). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Image 1 Alt Text | Mouse CD146 / MCAM Flow Cytometry (FC) 23302 |
| Image 1 URL | Source image |
Background Information
| Full Name | melanoma cell adhesion molecule |
| Description | The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region, and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumors, and thus has been suggested to play an important role in tumor progression and the development of metastasis in certain human carcinomas. |
| References |
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