| Catalog No. | Size | Price (USD) |
| 50963-T16-50 | 50 µL | $147.96 |
| 50963-T16-100 | 100 µL | $251.64 |
| 50963-T16-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Carboxypeptidase B2 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse Carboxypeptidase B2 |
| Immunogen | Recombinant Mouse Carboxypeptidase B2 / CPB2 protein (Catalog#50963-M08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse Carboxypeptidase B2 / CPB2 (Catalog#50963-M08H; Q9JHH6; Met1-Thr422). Carboxypeptidase B2 / CPB2 specific IgG was purified by Mouse Carboxypeptidase B2 / CPB2 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-1110032P04Rik Antibody; Anti-4930405E17Rik Antibody; Anti-Cpb2 Antibody; Anti-CPR Antibody; Anti-Cpu Antibody; Anti-TAFI Antibody
Background Information
| Full Name | carboxypeptidase B2 (plasma) |
| Description | Carboxypeptidase B2, also known as Carboxypeptidase U, Thrombin-activable fibrinolysis inhibitor, Plasma carboxypeptidase B, CPB2, is a secreted protein which belongs to the peptidase M14 family. Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). CPB2 is activated by thrombin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen. When it is activated by proteolysis at residue Arg92 by the thrombin / thrombomodulin complex. CPB2 cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. CPB2 exhibits carboxypeptidase activity and activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen. |
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