Anti-CD146/MCAM Antibody, Rabbit Polyclonal sinobiological 50794-T26
$243.00
In stock
SKU
50794-T26
| Catalog No. | Size | Price (USD) |
| 50794-T26-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-CD146/MCAM Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol), IHC-P (FAQ Protocol), ICC/IF (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse CD146/MCAM |
| Immunogen | Recombinant Mouse CD146/MCAM Protein (Catalog#50794-M08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse CD146/MCAM (rM CD146/MCAM; Catalog#50794-M08H; Q8R2Y2-1; Met1-Val563). CD146/MCAM specific IgG was purified by Mouse CD146/MCAM affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-1-gicerin Antibody; Anti-CD146 Antibody; Anti-CD149 Antibody; Anti-Mcam Antibody; Anti-Muc18 Antibody; Anti-s-endo Antibody; Anti-s-gicerin Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of Mouse CD146 in Mouse uterus with rabbit polyclonal antibody at 1:10000 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Mouse CD146/MCAM Immunohistochemistry(IHC) 38852 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of Mouse CD146 in Mouse uterus with rabbit polyclonal antibody at 1:10000 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Mouse CD146/MCAM Immunohistochemistry(IHC) 38853 |
| Image 2 URL | Source image |
| Image 3 Description | Immunochemical staining of Mouse CD146 in Mouse uterus with rabbit polyclonal antibody at 1:10000 dilution, formalin-fixed paraffin embedded sections. |
| Image 3 Alt Text | Mouse CD146/MCAM Immunofluorescence(IF) 38854 |
| Image 3 URL | Source image |
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Background Information
| Full Name | melanoma cell adhesion molecule |
| Description | The CD146 antigen, also known as melanoma cell adhesion molecule (MCAM) and MUC18, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region, and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. This protein is also expressed predominantly on metastatic lesions and advanced primary tumors, and thus has been suggested to play an important role in tumor progression and the development of metastasis in certain human carcinomas. |
| References |
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