| Catalog No. | Size | Price (USD) |
| 10186-R118-H-100 | 100 µg | $518.39 |
General Information
| Product name | Recombinant Anti-CD147/Basigin/EMMPRIN Antibody (HRP), Rabbit Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CD147/Basigin/EMMPRIN |
| Immunogen | Recombinant Human CD147 / EMMPRIN / Basigin Protein (Catalog#10186-H08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human CD147 / EMMPRIN / Basigin (rh CD147 / EMMPRIN / Basigin; Catalog#10186-H08H; NP_940991.1; Met1-His205), and conjugated with horseradish-peroxidase (HRP). |
| Source | Monoclonal Rabbit IgG Clone #118 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | HRP |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Protected from prolonged exposure to light. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-5F7 Antibody; Anti-CD147 Antibody; Anti-EMMPRIN Antibody; Anti-EMPRIN Antibody; Anti-HAb18G Antibody; Anti-OK Antibody; Anti-TCSF Antibody; Anti-UNQ6505/PRO21383 Antibody
Background Information
| Full Name | basigin (Ok blood group) |
| Description | CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis, embryo implantation, neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. Furthermore, CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently, CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression. Thus, CD147 and its antibody are used as an effective treatment for malignant cancers. |
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