| Catalog No. | Size | Price (USD) |
| 50135-R022-50 | 50 µL | $177.58 |
| 50135-R022-100 | 100 µL | $340.51 |
General Information
| Product name | Recombinant Anti-gp130/IL6ST Antibody, Rabbit Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse gp130/IL6ST |
| Immunogen | Recombinant Mouse IL6ST/gp130/CD130 Protein (Catalog#50135-M08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse IL6ST/gp130/CD130 (rM IL6ST/gp130/CD130; Catalog#50135-M08H; NP_034690.3; Met1-Glu617). |
| Source | Monoclonal Rabbit IgG Clone #022 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-5133400A03Rik Antibody; Anti-CD130 Antibody; Anti-D13Ertd699e Antibody; Anti-gp130 Antibody; Anti-Il6st Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of Mouse IL6ST(CD130) expression on BABL/c splenocytes. Cells were stained with purified anti-Mouse IL6ST(CD130), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Image 1 Alt Text | Mouse IL6ST/gp130/CD130 Flow Cytometry (FC) 15780 |
| Image 1 URL | Source image |
Background Information
| Full Name | interleukin 6 signal transducer |
| Description | Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta, or CD130) is a transmembrane protein that is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively, spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1, and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events. |
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