| Catalog No. | Size | Price (USD) |
| 50440-T24-50 | 50 µL | $147.96 |
| 50440-T24-100 | 100 µL | $251.64 |
| 50440-T24-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-ICAM-1/CD54 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol), IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse ICAM-1/CD54 |
| Immunogen | Recombinant Mouse ICAM-1/CD54 Protein (Catalog#50440-M08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse ICAM-1/CD54 (rM ICAM-1/CD54; Catalog#50440-M08H; NP_034623.1; Met1-Asn485). ICAM-1/CD54 specific IgG was purified by Mouse ICAM-1/CD54 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CD54 Antibody; Anti-Icam-1 Antibody; Anti-Icam1 Antibody; Anti-Ly-47 Antibody; Anti-MALA-2 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of mouse ICAM1 in mouse kidney with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Mouse ICAM-1/CD54 Immunohistochemistry(IHC) 18529 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of mouse ICAM1 in mouse kidney with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Mouse ICAM-1/CD54 Immunohistochemistry(IHC) 18530 |
| Image 2 URL | Source image |
Background Information
| Full Name | intercellular adhesion molecule 1 |
| Description | Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and animal models of atherosclerosis. Additionally, ICAM-1 has been implicated in the progression of autoimmune diseases. ICAM-1 is a ligand for LFA-1(integrin). When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 interaction and then transmigrate into tissues. Presence with heavy glycosylation and other structural characteristics, ICAM-1 possesses binding sites for some immune-associated ligands and serves as the binding site for entry of the major group of human Rhinovirus (HRV) into various cell types. ICAM-1 also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease. Previous studies have shown that ICAM-1 is involved in inflammatory reactions and that a defect in ICAM-1 gene inhibits allergic contact hypersensitivity. |
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| References |
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