| Catalog No. | Size | Price (USD) |
| 50460-T24-50 | 50 µL | $147.96 |
| 50460-T24-100 | 100 µL | $251.64 |
| 50460-T24-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-IGFBP-6 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol), IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse IGFBP-6 |
| Immunogen | Recombinant Mouse IGFBP6 / IBP6 Protein (Catalog#50460-M08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse IGFBP6 / IBP6 (rM IGFBP6 / IBP6; Catalog#50460-M08H; NP_032370.2; Met1-Gly238). IGFBP6 / IBP6 specific IgG was purified by Mouse IGFBP6 / IBP6 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-IGFBP-6 Antibody; Anti-Igfbp6 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of mouse IGFBP6 in mouse skeletal muscle with rabbit polyclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| Image 1 Alt Text | Mouse IGFBP6 / IBP6 Immunohistochemistry(IHC) 3261 |
| Image 1 URL | Source image |
Background Information
| Full Name | insulin-like growth factor binding protein 6 |
| Description | Insulin-like growth factor-binding protein 6 (IGFBP6) is a 24-kDa protein that binds insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. The Insulin-like growth factor-binding protein also known as IGFBP serves as a carrier protein for Insulin-like growth factor 1. IGFBPs are distinct but are sharing regions with strong homology. All members of the IGFBP family bind IGF-I and IGF-II with about equal affinity. Insulin-like growth factor (IGF) binding proteins (IGFBPs) have been shown to either inhibit or enhance the action of IGF or act in an IGF-independent manner in the prostate. IGF-binding protein-4 (IGFBP-4) inhibits IGF-I action in vitro and is the most abundant IGFBP in the rodent arterial wall. IGFBP6 is directly downregulated by the beta-catenin/TCF complex in desmoid tumors, and imply a role for the IGF axis in the proliferation of desmoid tumors. There is mounting evidence that the structure of the IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence, and IGF affinity. |
| References |
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