| Catalog No. | Size | Price (USD) |
| 11620-MM09-B-100 | 100 µg | $370.28 |
General Information
| Product name | Anti-CD200RLa Antibody (Biotin), Mouse Monoclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CD200RLa |
| Immunogen | Recombinant Human CD200RLa / CD200R1L protein (Catalog#11620-H08H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD200RLa / CD200R1L (rh CD200RLa / CD200R1L; Catalog#11620-H08H; AAT00538.1; Met1-Leu239) and then biotinylated. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and then biotinylated. |
| Source | Monoclonal Mouse IgG1 Clone #6D6C1 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Biotin |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CD200R2 Antibody; Anti-CD200RLa Antibody
Background Information
| Full Name | CD200 receptor 1 like |
| Description | Cell surface glycoprotein CD2 receptor 2, also known as Cell surface glycoprotein CD2 receptor 1-like, Cell surface glycoprotein OX2 receptor 2, CD2 receptor-like 2, CD2Rla, CD2R1L and CD2R2, is a single-pass type I membrane protein which belongs to theCD2R family. CD2R1L / CD2R2. It contains oneIg-like C2-type (immunoglobulin-like) domain and oneIg-like V-type (immunoglobulin-like) domain. CD2 is a transmembrane protein delivering immunoregulatory signals after engagement of CD2R. A family of CD2Rs exist ( CD2R1, CD2R2, CD2R3, CD2R4 ) with different tissue expression and functional activity. In the presence of anti-CD2R2 / CD2R3 monoclonal antibodies (mAbs), bone-marrow cells cultured in the presence of (interleukin [IL]-4+granulocyte-macrophage colony-stimulating factor) differentiate into dendritic cells (DCs), which induce CD4+CD25+ Treg. Interaction between the relatively ubiquitously expressed molecule CD2 and one of its receptors, CD2R1, resulted in direct suppression of alloreactivity, engagement of alternate receptors led instead to altered differentiation of dendritic cells (DCs) from marrow precursors, which could in turn foster development of Foxp3(+) regulatory T cells. Unlike anti-CD2R1, anti-CD2R2 both promotes development of DCs with capacity to induce Treg and directly augments thymocyte production of Treg. |
| References |
|
title: CD200R1L is a functional evolutionary conserved activating receptor in human neutrophils
authors: M. Inês Pascoal Ramos; Can Keşmir; ...; Michiel Vlist
journal: Journal of leukocyte biology
date: 2021-04-22
doi: 10.1002/jlb.2a0520-334r
cited_by_count: 3
techniques: Incubation; Western Blot
bioz_score: 90
