| Catalog No. | Size | Price (USD) |
| 50255-RP01-100 | 100 µL | $147.96 |
| 50255-RP01-200 | 200 µL | $251.64 |
| 50255-RP01-400 | 400 µL | $355.32 |
General Information
| Product name | Anti-Kallikrein 6 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse Kallikrein 6 |
| Immunogen | Recombinant Mouse KLK6 / Kallikrein 6 / Neurosin protein |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse KLK6 / Kallikrein 6 / Neurosin (NP_035307.2; Met 8-Leu 253). Total IgG was purified by Protein A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-BSP Antibody; Anti-Bssp Antibody; Anti-Klk29 Antibody; Anti-MSP Antibody; Anti-neurosin Antibody; Anti-Prss18 Antibody; Anti-Prss9 Antibody
Background Information
| Full Name | kallikrein-related peptidase 6 |
| Description | KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease that exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein, and extracellular matrix proteins such as fibronectin, laminin, vitronectin, and collagen. KLK6 degrades alpha-synuclein and prevents its polymerization, indicating that KLK6 may be involved in the pathogenesis of Parkinson's disease and other synucleinopathies. Klk7 may be involved in the regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. |
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