| Catalog No. | Size | Price (USD) |
| 50057-RP02-50 | 50 µL | $147.96 |
| 50057-RP02-100 | 100 µL | $251.64 |
| 50057-RP02-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-Meprin alpha/MEP1A Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse Meprin alpha/MEP1A |
| Immunogen | Recombinant Mouse MEP1A protein (Catalog#50057-M08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse MEP1A (rM MEP1A; Catalog#50057-M08H; NP_032611.2; Met 1-Arg 615). MEP1A specific IgG was purified by mouse MEP1A affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-Mep-1 Antibody; Anti-Mep-1a Antibody; Anti-Mep1 Antibody; Anti-Mep1a Antibody
Image / Experimental Information
| Image 1 Description | Anti-MEP1A rabbit polyclonal antibody at 1:500 dilution Lane A: A431 Membrane Lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size:84 kDa Observed band size:70 kDa (We are unsure as to the identity of these extra bands.) |
| Image 1 Alt Text | Mouse MEP1A Western blot (WB) 13639 |
| Image 1 URL | Source image |
Background Information
| Full Name | meprin A, alpha (PABA peptide hydrolase) |
| Description | Meprin A subunit alpha, also known as MEP1A, and Endopeptidase-2, is a single-pass type I membrane protein that belongs to the peptidase M12A family. MEP1A contains one EGF-like domain, one MAM domain, and one MATH domain. Meprins are unique plasma membrane and secreted metalloproteinases that are highly regulated at the transcriptional and post-translational levels. Meprin alpha and beta subunits are abundantly expressed in kidney and intestinal epithelial cells, are secreted into the urinary tract and intestinal lumen and are found in leukocytes and cancer cells under certain conditions. Meprins are capable of proteolytically degrading extracellular matrix proteins, processing bioactive proteins, and play a role in inflammatory processes. Meprin A and B are highly regulated, secreted and cell-surface homo- and hetero-oligomeric enzymes. Meprins are abundantly expressed in the kidney and intestine. The multidomain alpha and beta subunits have high sequence identity. They have very different substrate specificities, oligomerization potentials, and are differentially regulated. Meprin A appears to be an important therapeutic target and urinary excretion appears to be a potential biomarker of acute kidney injury ( AKI ). |
| References |
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