Anti-CD2BP2 Antibody, Rabbit Polyclonal sinobiological 201328-T36

$143.00
In stock
SKU
201328-T36
Catalog No.SizePrice (USD)
201328-T36-5050 µL$147.96
201328-T36-100100 µL$251.64
201328-T36-200200 µL$355.32

General Information

Product nameAnti-CD2BP2 Antibody, Rabbit Polyclonal
Validated applicationsWB (FAQ Protocol), IP (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman CD2BP2
ImmunogenE. coli-derived Human CD2BP2 fragment
PreparationProduced in rabbits immunized with E. coli-derived Human CD2BP2 fragment, and purified by antigen affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A & Antigen Affinity
FormulationPBS, pH7.0 with 0.03% Proclin300
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-FWP010 Antibody; Anti-KIAA1178 Antibody; Anti-LIN1 Antibody; Anti-PPP1R59 Antibody; Anti-Snu40 Antibody; Anti-U5-52K Antibody

Image / Experimental Information

Image 1 DescriptionAnti-CD2BP2 rabbit polyclonal antibody at 1:500 dilution Lane A: HeLa Whole Cell Lysate Lane B: Jurkat Whole Cell Lysate Lane C: U-251MG Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:38 kDa Observed band size:55 kDa (We are unsure as to the identity of these extra bands.)
Image 1 Alt TextHuman CD2BP2 Western blot (WB) 28735
Image 1 URLSource image
Image 2 DescriptionAnti-CD2BP2 rabbit polyclonal antibody at 1:500 dilution Lane A: HeLa Whole Cell Lysate Lane B: Jurkat Whole Cell Lysate Lane C: U-251MG Whole Cell Lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:38 kDa Observed band size:55 kDa (We are unsure as to the identity of these extra bands.)
Image 2 Alt TextHuman CD2BP2 Immunoprecipitation(IP) 28736
Image 2 URLSource image

Background Information

Full NameCD2 (cytoplasmic tail) binding protein 2
DescriptionThe adaptor protein CD2BP2, originally identified as a binding partner of the adhesion molecule CD2, is a pre-spliceosomal assembly factor that utilizes its glycine-tyrosine-phenylalanine (GYF) domain to co-localize with spliceosomal proteins. CD2BP2 confers binding to proline-rich sequences (PRS) via its GYF domain. CD2BP2 plays a crucial role in CD2-triggered T cell activation and nuclear splicing. CD2BP2 is a non-redundant splicing factor that is essential for embryonic development and podocyte integrity.
References
  1. Kofler M, et al. (2004) Recognition sequences for the gyf domain reveal a possible spliceosomal function of cd2bp2. J Biol Chem 279 (27): 28292-28297.
  2. Heinze M, et al. (2007) Investigating the functional role of cd2bp2 in t cells. Int Immunol 19 (11): 1313-1318.
  3. Albert GI, et al. (2015) The gyf domain protein cd2bp2 is critical for embryogenesis and podocyte function. J Mol Cell Biol 7 (5): 402-414.

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