Anti-MRPL45 Antibody, Rabbit Polyclonal sinobiological 200958-T10

$143.00
In stock
SKU
200958-T10
Catalog No.SizePrice (USD)
200958-T10-5050 µL$147.96
200958-T10-100100 µL$251.64
200958-T10-200200 µL$355.32

General Information

Product nameAnti-MRPL45 Antibody, Rabbit Polyclonal
Validated applicationsIHC-P (FAQ Protocol), ICC/IF (FAQ Protocol)
Species reactivityReacts with: Human
SpecificityHuman MRPL45
ImmunogenE. coli-derived Human MRPL45 fragment
PreparationProduced in rabbits immunized with E. coli-derived Human MRPL45 fragment, and purified by antigen affinity chromatography.
SourcePolyclonal Rabbit IgG
PurificationProtein A & Antigen Affinity
FormulationPBS, pH7.0 with 0.03% Proclin300
ConjugateUnconjugated
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-L45mt Antibody; Anti-Mba1 Antibody; Anti-MGC11321 Antibody; Anti-mL45 Antibody; Anti-MRP-L45 Antibody

Image / Experimental Information

Image 1 DescriptionImmunochemical staining of human MRPL45 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
Image 1 Alt TextHuman MRPL45 Immunohistochemistry(IHC) 24239
Image 1 URLSource image
Image 2 DescriptionImmunochemical staining of human MRPL45 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
Image 2 Alt TextHuman MRPL45 Immunofluorescence(IF) 24240
Image 2 URLSource image

Background Information

Full Namemitochondrial ribosomal protein L45
DescriptionMRPL45 (Mitochondrial Ribosomal Protein L45) is a Protein Coding gene. The MRPL45 gene, located on 17q12, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog. MRPL45 belongs to the mitochondrion-specific ribosomal protein mL45 family. This gene encodes a 39S subunit protein. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 2p and 17q. MRPL45 is widely expressed in the thyroid, kidney, and other tissues. Diseases associated with MRPL45 include Fanconi Anemia, Complementation Group L, and Mitochondrial Complex Iv Deficiency. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation.
References
  1. Yagi M, et al. (2012) P32/gc1qr is indispensable for fetal development and mitochondrial translation: Importance of its rna-binding ability. Nucleic Acids Res 40 (19): 9717-9737.
  2. Pharoah PD, et al. (2013) Gwas meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat Genet 45 (4): 362-370, 370e361-362.
  3. Brown A, et al. (2014) Structure of the large ribosomal subunit from human mitochondria. Science 346 (6210): 718-722.

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