Produced in rabbits immunized with E. coli-derived Human MRPL45 fragment, and purified by antigen affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
PBS, pH7.0 with 0.03% Proclin300
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.
MRPL45 (Mitochondrial Ribosomal Protein L45) is a Protein Coding gene. The MRPL45 gene, located on 17q12, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog. MRPL45 belongs to the mitochondrion-specific ribosomal protein mL45 family. This gene encodes a 39S subunit protein. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 2p and 17q. MRPL45 is widely expressed in the thyroid, kidney, and other tissues. Diseases associated with MRPL45 include Fanconi Anemia, Complementation Group L, and Mitochondrial Complex Iv Deficiency. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation.
References
Yagi M, et al. (2012) P32/gc1qr is indispensable for fetal development and mitochondrial translation: Importance of its rna-binding ability. Nucleic Acids Res 40 (19): 9717-9737.
Pharoah PD, et al. (2013) Gwas meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat Genet 45 (4): 362-370, 370e361-362.
Brown A, et al. (2014) Structure of the large ribosomal subunit from human mitochondria. Science 346 (6210): 718-722.