| Catalog No. | Size | Price (USD) |
| 203834-T08-50 | 50 µL | $147.96 |
| 203834-T08-100 | 100 µL | $251.64 |
| 203834-T08-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-MTHFD2 Antibody, Rabbit Polyclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human MTHFD2 |
| Immunogen | E. coli-derived Human MTHFD2 fragment |
| Preparation | Produced in rabbits immunized with E. coli-derived Human MTHFD2 fragment, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | PBS, pH7.0 with 0.03% Proclin300 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-NMDMC Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human MTHFD2 in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human MTHFD2 Immunohistochemistry(IHC) 22706 |
| Image 1 URL | Source image |
Background Information
| Full Name | methylenetetrahydrofolate dehydrogenase 2, methenyltetrahydrofolate cyclohydrolase |
| Description | Methylenetetrahydrofolate dehydrogenase (MTHFD2), a dual-functional metabolic enzyme, is a tetramethylfolate dehydrogenase enzyme involved in folate metabolism. The folate-coupled metabolic enzyme MTHFD2 is overexpressed in many tumor types and required for cancer cell proliferation and is therefore of interest as a potential cancer therapeutic target. However, recent evidence suggests that MTHFD2 has a non-enzymatic function which may underlie the dependence of cancer cells on this protein. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is specifically enhanced in cancer. MTHFD2 plays a key role in one-carbon (1C) metabolism in human mitochondria, and its high expression correlates with poor survival of patients with various types of cancer. An isozyme-selective MTHFD2 inhibitor is highly attractive for potential use in cancer treatment. MTHFD2 is a functional target gene of miR-33a-5p. miR-33a-5p inhibits the growth and migration of CRC by targeting MTHFD2. |
| References |
|
-HD12AU2126-100-human-kidney-IHC-P.png){kind=link}