| Size | Price (USD) |
| 200μL | $399.00 |
| 120μL | $240.00 |
| 60μL | $143.00 |
| 20μL | $73.00 |
Product Details
| Abbre | Phospho-ERK 1/2 (Tyr222/205) |
| Synonyms | ERK-1, ERK1, ERT2, Extracellular signal-regulated kinase 1, Insulin-stimulated MAP2 kinase, MAP kinase 3, MAP kinase isoform p44, MAPK 3, MAPK3, Microtubule-associated protein 2 kinase, Mitogen-activated protein kinase 3, PRKM3, p, p44-MAPK |
| Swissprot | P27361 P28482 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | 4D4 |
| Isotype | IgG |
| Applications | IHC-p |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 0.5% protein protectant and 50% glycerol. |
| Purification Method | Protein A purification |
| Immunogen | Synthetic Peptide of Phospho-ERK 1/2 (Tyr222/205) |
| Research Areas | Cancer, Signal Transduction, Neuroscience |
| Cellular Localization | Nucleus. |
Product Description
Background: Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
Storage and Shipping
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
Additional Information
| Verified Samples | Verified Samples in IHC: Human colon carcinoma, Human breast carcinoma |
| Dilution | IHC 1:100-200 |
![Elab Fluor ® 647 Anti-Human CD135 Antibody[BV10(BV10A4)] (AN00407M) elabscience](https://www.biogege.com/media/catalog/product/cache/af3f9de669682211425a7c3e7baf6e62/0/q/AN00407M_1_386e8e5b49.jpg)