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Biotinylated Cynomolgus ITPRIPL1 (C-6His-Avi)(Cat. No.:CY179) novoprotein

Biotinylated Cynomolgus ITPRIPL1 (C-6His-Avi)(Cat. No.:CY179) novoprotein

Name: Biotinylated Cynomolgus ITPRIPL1 (C-6His-Avi)(Cat. No.:CY179) novoprotein
SKU: CY179
Price: 375 USD
Availability: InStock

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$375.00

In stock

SKU

CY179

20μg: $375 100μg: $938

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Description

Biotinylated Recombinant Cynomolgus Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 is produced by our Mammalian expression system and the target gene encoding His25-Gly103 is expressed with a 6His, Avi tag at the C-terminus.

Product Details

Item	Details
Known As	Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1; ITPRIPL1; KIAA1754L; CD3L1
Mol Mass	11.9 kDa
APMol Mass	14-18 kDa, reducing conditions
Formulation Description	Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Endotoxin	＜1EU/μg as determined by LAL test.
Reconstitution	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping	The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.

Background

Cancer immunotherapy has transformed treatment possibilities, but its effectiveness differs significantly among patients, indicating the presence of alternative pathways for immune evasion. Here, we show that ITPRIPL1 functions as an inhibitory ligand of CD3ε, and its expression inhibits T cells in the tumor microenvironment. 1,4,5-triphosphate receptor-interacting protein-like 1 (ITPRIPL1), a natural CD3 ligand, to evade immune surveillance and promote tumor growth. ITPRIPL1, is also a remarkable NSCLC biomarker. Detecting ITPRIPL1 in tumors can contribute to better diagnosis, CD8 positive T cell infiltration revelation, disease progression surveillance, and prognosis prediction.