Cuproptosis Essentials Antibody Sampler Kit PK30028 proteintech
$449.00
In stock
SKU
PK30028
| Catalog Number | PK30028 |
| Synonyms | United States |
| Reactivity | Target Dependent |
| Applications | Target Dependent |
| Host / Isotype | Rabbit/Mouse |
| Antigen | Catalog No. Host, clonality Tested Reactivity Applications Volume |
| FDX1 | 82957-2-RR Rabbit Monoclonal H WB, IHC, IF/ICC, FC (Intra) 20 uL |
| DLAT | 83654-3-RR Rabbit Monoclonal H, M, Rt WB, IHC, IF/ICC, FC (Intra) 20 uL |
| LIAS | 11577-1-AP Rabbit Polyclonal H, M, Rt WB, IHC, IF, IP 20 uL |
| SLC31A1 | 67221-1-Ig Mouse Monoclonal H WB, IHC, IF-P 20 uL |
| DLD | 67702-1-Ig Mouse Monoclonal H, M, Rt WB, IHC 20 uL |
| Range | {{ptg:compareRange}} |
| Test | 20T, 100T, 500T |
Cuproptosis is a novel from of cell death that is triggered by the accumulation of excess copper ions within the cell. This promotes aberrant lipolyation and protein aggregation, resulting in oxidative stress and impaired mitochondrial activity. Key regulators of cuproptosis include DLAT, FDX1, and LIAS. DLAT, a key component of the pyruvate dehydrogenase complex (PDC), is required for lipoylation and the activation of enzymes in the tricarboxylic acid cycle. During cuproptosis, increased copper levels cause aberrant lipoylation and aggregation of DLAT, resulting in mitochondrial dysfunction and cell death. LIAS, which is required for lipoic acid synthesis, ensures that TCA cycle enzymes such as DLAT remain stable and active. Disruption in LIAS function causes lipoylated proteins to aggregate pathologically, contributing to cuproptosis. FDX1 helps to mediate the celluar response to copper-induced stress. It contributes toward the reduction ofiron-sulfur (Fe-S) clusters and regulation of copper ion homeostasis and redox processes. Dyresgulation of additional proteins such as SLC31A1 and DLD may also contribute to increased copper uptake and senstivity to cuproptosis respectively. Standard Protocols Click here to view our standard protocols for various applications including WB, IP, IHC, IF, FC, and ELISA. Cited in Article as PK30028, Cuproptosis Essentials Antibody Sampler Kit, Proteintech, IL, USA Documentation Datasheet Cuproptosis Essentials Antibody Sampler Kit Datasheet
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