DOK3 Polyclonal antibody 15749-1-AP proteintech
$149.00
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SKU
15749-1-AP
| Catalog Number | 15749-1-AP |
| Synonyms | docking protein 3, DOK3, DOKL |
| Host | Rabbit |
| Reactivity | human, mouse, rat |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IHC, ELISA |
| Applications | WB, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | K-562 cells, Ramos cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:500-1:3000 |
| Positive WB detected in | K-562 cells, Ramos cells |
| Western Blot (WB) | WB : 1:500-1:3000 |
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag8221 Product name: Recombinant human DOK3 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-330 aa of BC004564 Sequence: MDPLETPIKDGILYQQHVKFGKKCWRKVWALLYAGGPSGVARLESWEVRDGGLGAAGDRSAGPGRRGERRVIRLADCVSVLPADGESCPRDTGAFLLTTTERSHLLAAQHRQAWMGPICQLAFPGTGEASSGSTDAQSPKRGLVPMEENSIYSSWQEVGEFPVVVQRTEAATRCQLKGPALLVLGPDAIQLREAKGTQALYSWPYHFLRKFGSDKILLGTPGVSLLICKGERTDDVSGIILDESLLRAYSVPGAGGHSRVQDSLGPVLREPTFQGERSFLKTSMLRSLLCSCSWRHPRSQPCTQASCLQGSDCPAPHRNSTSAAHTLGTS Predict reactive species |
| Full Name | docking protein 3 |
| Calculated Molecular Weight | 496aa,53 kDa; 330aa,36 kDa |
| Observed Molecular Weight | 53 kDa |
| GenBank Accession Number | BC004564 |
| Gene Symbol | DOK3 |
| Gene ID (NCBI) | 79930 |
| RRID | AB_2095099 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q7L591 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| WB protocol for DOK3 antibody 15749-1-AP | Download protocol |
| human | IHC Int Immunopharmacol Elevated expression of DOK3 indicates high suppressive immune cell infiltration and unfavorable prognosis of gliomas. Authors - Xiu Liu View Article |
| Citations | 1 |
| Dilutions | WB : 1:500-1:3000 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
The adaptor proteins downstream of kinase 1 (DOK1) to DOK3 are mainly found in immune cells, and they are closely related, with some functional redundancy, although each DOK protein has distinct properties and functions. DOK1 to DOK3 inhibit LPS responses. DOK proteins have an N-terminal pleckstrin homology (PH) domain, a phosphotyrosine-binding (PTB) domain, and four tyrosine-containing motifs that can bind to Src homology 2 (SH2) domains when phosphorylated. DOK3 was also shown to have an inhibitory role as it restricts Ca2+ and JNK activation in B cell receptor signaling. The MW of this protein is 53 kDa, and this antibody specially recognises the 53 kDa protein. Protocols Product Specific Protocols WB protocol for DOK3 antibody 15749-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- Elevated expression of DOK3 indicates high suppressive immune cell infiltration and unfavorable prognosis of gliomas.
Journal: Int Immunopharmacol | Authors: Xiu Liu | Species: human | Application: IHC
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