MAX Polyclonal antibody 10426-1-AP proteintech
$149.00
In stock
SKU
10426-1-AP
| Catalog Number | 10426-1-AP |
| Synonyms | bHLHd4, bHLHd5, bHLHd6, bHLHd7, bHLHd8 |
| Host | Rabbit |
| Reactivity | human and More (1) |
| Reactivity | human, mouse |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IHC, IF, IP, CoIP, chIP, ELISA |
| Applications | WB, IP, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | HEK-293 cells, PC-3 cells |
| Tested Applications — Positive IP detected in | PC-3 cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:500-1:1000 |
| Recommended Dilutions — Immunoprecipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
| Positive WB detected in | HEK-293 cells, PC-3 cells |
| Positive IP detected in | PC-3 cells |
| Western Blot (WB) | WB : 1:500-1:1000 |
| Immunoprecipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
| Tested Reactivity | human |
| Cited Reactivity | human, mouse |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag0680 Product name: Recombinant human MAX protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-151 aa of BC003525 Sequence: MSDNDDIEVESDADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASRAQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDNSLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS Predict reactive species |
| Full Name | MYC associated factor X |
| Calculated Molecular Weight | 18 kDa |
| Observed Molecular Weight | 22 kDa |
| GenBank Accession Number | BC003525 |
| Gene Symbol | MAX |
| Gene ID (NCBI) | 4149 |
| RRID | AB_2141660 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P61244 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IP protocol for MAX antibody 10426-1-AP | Download protocol |
| WB protocol for MAX antibody 10426-1-AP | Download protocol |
| mouse | WB Cancer Cell MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer. Authors - Arnaud Augert KO Validated View Article |
| human | WB,ChIP Elife Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness. Authors - Haritha Mathsyaraja View Article |
| Inmaculada (Verified Customer) (02-12-2026) | I used this antibody for ChIP, Western blot, and immunofluorescence, and it performs very well. Life is much easier when you have a good antibody. Applications: Western Blot, Immunoprecipitation, ChIP, Protein purification Primary Antibody Dilution: 1/1000 Cell Tissue Type: mouse embryonic stem cells |
| Citations | 24 |
| Dilutions | WB : 1:500-1:1000 IP : 0.5-4.0 ug for IP and 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate for WB |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
Max, a member of MAX family, contains a basic helix-loop-helix (bHLH) domain, is a transcription regulator. MAX can form a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, while the MAD-MAX complex is a repressor. MAX could dimerizated with another bHLH protein to form a heterodimer, such MYC or MAD. Thus bands recognized by this antibody much larger than predicted. Protocols Product Specific Protocols IP protocol for MAX antibody 10426-1-AP Download protocol WB protocol for MAX antibody 10426-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer.
Journal: Cancer Cell | Authors: Arnaud Augert KO Validated | Species: mouse | Application: WB - A MYC inhibitor selectively alters the MYC and MAX cistromes and modulates the epigenomic landscape to regulate target gene expression.
Journal: Sci Adv | Authors: Austin G Holmes | Species: human | Application: WB - AKR1B10 dictates c-Myc stability to suppress colorectal cancer metastasis via PP2A nitration
Journal: Sci Adv | Authors: Xiaoxue Wu | Application: WB - PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression.
Journal: Nat Commun | Authors: Xianchun Lan | Species: human | Application: WB - NKD1 enhances colon cancer progression by inhibiting the autophagic degradation of MYC
Journal: Cell Death Dis | Authors: Wenbin Lu - Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness.
Journal: Elife | Authors: Haritha Mathsyaraja | Species: human | Application: WB,ChIP - Targeting TCF21-TCF3 heterodimer in tumor-associated pericytes attenuates hematogenous metastasis by restoring pericyte gatekeeper function.
Journal: Cell Rep Med | Authors: Wenqian Yin | Species: human | Application: CoIP - A MYC inhibitor selectively alters the MYC and MAX cistromes and modulates the epigenomic landscape to regulate target gene expression.
Journal: Sci Adv | Authors: Austin G Holmes | Species: human | Application: WB - AKR1B10 dictates c-Myc stability to suppress colorectal cancer metastasis via PP2A nitration
Journal: Sci Adv | Authors: Xiaoxue Wu | Application: WB - MAX inactivation deregulates the MYC network and induces neuroendocrine neoplasia in multiple tissues
Journal: Sci Adv | Authors: Brian Freie | Species: mouse | Application: IP - NKD1 enhances colon cancer progression by inhibiting the autophagic degradation of MYC
Journal: Cell Death Dis | Authors: Wenbin Lu - Novel dual-targeting c-Myc inhibitor D347-2761 represses myeloma growth via blocking c-Myc/Max heterodimerization and disturbing its stability.
Journal: Cell Commun Signal | Authors: Ruosi Yao | Species: human | Application: WB - Single-cell and spatial transcriptomic analyses reveal heterogeneity characteristics and specific cell subtype regulators in growth hormone-secreting pituitary adenomas
Journal: Int J Surg | Authors: Yu Zhang | Species: human | Application: IHC - A program of successive gene expression in mouse one-cell embryos
Journal: Cell Rep | Authors: Maki Asami | Species: mouse | Application: IF - NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells.
Journal: Cell Rep | Authors: Yuetong Wang | Species: human | Application: WB - Salvianolic acid B and Senkyunolide I synergistically alleviate cardiac hypertrophy and regulate MAP3K1 signaling
Journal: Chin Med | Authors: Changtong Liu | Application: WB - Endogenous protein tagging coupled with a CRISPR screening approach identifies UBE3C as a potential MYC oncogene regulator.
Journal: Sci Rep | Authors: Marcel Seibert | Species: human | Application: WB - Myc/Max dependent intronic long antisense noncoding RNA, EVA1A-AS, suppresses the expression of Myc/Max dependent anti-proliferating gene EVA1A in a U2 dependent manner.
Journal: Sci Rep | Authors: Svenja E Niehus | Species: human | Application: chIP - Role for carbohydrate response element-binding protein (ChREBP) in high glucose-mediated repression of long noncoding RNA Tug1.
Journal: J Biol Chem | Authors: Jianyin Long | Species: human | Application: chIP - Cell-based high-throughput screening using a target-NanoLuc fusion construct to identify molecular glue degraders of c-Myc oncoprotein.
Journal: RSC Chem Biol | Authors: Muyu Xu | Species: human | Application: WB,CoIP - MAX deficiency impairs human endometrial decidualization through down-regulating OSR2 in women with recurrent spontaneous abortion.
Journal: Cell Tissue Res | Authors: Weixu Ma | Species: human | Application: ChIP - Integrated analysis of mRNA-seq and miRNA-seq reveals the potential roles of Egr1, Rxra and Max in kidney stone disease
Journal: Urolithiasis | Authors: Linxi Huang | Species: mouse,human | Application: IHC - MAX inactivation deregulates the MYC network and induces neuroendocrine neoplasia in multiple tissues
Journal: bioRxiv | Authors: Brian Freie | Species: mouse | Application: WB - Loss of MGA repression mediated by an atypical polycomb complex promotes tumor progression and invasiveness.
Journal: Elife | Authors: Haritha Mathsyaraja | Species: human | Application: WB,ChIP - GCN5-Mediated Lactylation of YY1 Promotes Diabetic Cardiomyopathy by Activating Twist1-Dependent EndMT.
Journal: FASEB J | Authors: Jingjing Liu | Species: human | Application: WB
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