TTF1/NKX2-1 Polyclonal antibody 21777-1-AP proteintech
$149.00
In stock
SKU
21777-1-AP
| Catalog Number | 21777-1-AP |
| Synonyms | TTF1, TTF1; NKX2-1, BHC, Homeobox protein Nkx 2.1, Homeobox protein Nkx-2.1 |
| Host | Rabbit |
| Reactivity | human, mouse, rat |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IHC, IP, ELISA |
| Applications | WB, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | HeLa cells, mouse brain tissue, mouse lung tissue, rat brain tissue |
| Recommended Dilutions — Western Blot (WB) | WB : 1:500-1:2000 |
| Positive WB detected in | HeLa cells, mouse brain tissue, mouse lung tissue, rat brain tissue |
| Western Blot (WB) | WB : 1:500-1:2000 |
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human, mouse |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide Predict reactive species |
| Full Name | NK2 homeobox 1 |
| Calculated Molecular Weight | 42 kDa |
| Observed Molecular Weight | 45-50 kDa |
| GenBank Accession Number | NM_003317 |
| Gene Symbol | TTF1 |
| Gene ID (NCBI) | 7080 |
| RRID | AB_2878919 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P43699 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| WB protocol for TTF1/NKX2-1 antibody 21777-1-AP | Download protocol |
| human | WB Environ Pollut PFOA substitute GenX at a sub-cytotoxic level exhibits thyroid-disrupting effects by inhibiting the expression of Thyroid Transcription Factor 1 Authors - Shuangjun He View Article |
| mouse,human | IP Cancer Res Loss of CDKN2A Enhances the Efficacy of Immunotherapy in EGFR Mutant Non-Small Cell Lung Cancer Authors - Simeng Wang View Article |
| mouse | IHC Phytother Res Chlorogenic Acid Regulates Macrophage Polarization in LUAD by Inhibiting Taurodeoxycholic Acid Metabolism to Block the TGR5/STAT3 Signaling Pathway. Authors - Xiwu Rao View Article |
| Citations | 6 |
| Dilutions | WB : 1:500-1:2000 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
NKX2-1, also named as NKX2A, TITF1 and TTF1, belongs to the NK-2 homeobox family. It is a transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. NKX2-1 is crucial in the maintenance of the thyroid differentiation phenotype. It may play a role in lung development and surfactant homeostasis. Defects in NKX2-1 are the cause of benign hereditary chorea (BHC), choreoathetosis, hypothyroidism, and neonatal respiratory distress (CHNRD). The antibody is specific to NKX2-1. Protocols Product Specific Protocols WB protocol for TTF1/NKX2-1 antibody 21777-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- Role of estrogen receptors in thyroid toxicity induced by mono (2-ethylhexyl) phthalate via endoplasmic reticulum stress: An in vitro mechanistic investigation
Journal: Environ Toxicol Pharmacol | Authors: Qi Xu | Species: human | Application: WB - PFOA substitute GenX at a sub-cytotoxic level exhibits thyroid-disrupting effects by inhibiting the expression of Thyroid Transcription Factor 1
Journal: Environ Pollut | Authors: Shuangjun He | Species: human | Application: WB - Loss of CDKN2A Enhances the Efficacy of Immunotherapy in EGFR Mutant Non-Small Cell Lung Cancer
Journal: Cancer Res | Authors: Simeng Wang | Species: mouse,human | Application: IP - Prenatal amoxicillin exposure impairs mouse alveolar development via Tet3-mediated hypo-hydroxymethylation of Nkx2-1 promoter.
Journal: Toxicol Appl Pharmacol | Authors: Weisheng Li | Species: mouse | Application: WB - Chlorogenic Acid Regulates Macrophage Polarization in LUAD by Inhibiting Taurodeoxycholic Acid Metabolism to Block the TGR5/STAT3 Signaling Pathway.
Journal: Phytother Res | Authors: Xiwu Rao | Species: mouse | Application: IHC - Tapt1 deficiency in mice impairs pulmonary lipid homeostasis and normal postnatal respiration by targeting ABCA3 for autophagy-lysosomal degradation.
Journal: J Genet Genomics | Authors: Dandan Tan
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