SLCO1B3/OATP1B3 Polyclonal antibody 22815-1-AP proteintech
$149.00
In stock
SKU
22815-1-AP
| Catalog Number | 22815-1-AP |
| Synonyms | OATP 8, OATP1B3, OATP8, SLCO1B3, Liver-specific organic anion transporter 2 |
| Host | Rabbit |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IHC, ELISA |
| Applications | WB, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | HeLa cells, L02 cells, human placenta tissue |
| Recommended Dilutions — Western Blot (WB) | WB : 1:500-1:1000 |
| Positive WB detected in | HeLa cells, L02 cells, human placenta tissue |
| Western Blot (WB) | WB : 1:500-1:1000 |
| Tested Reactivity | human |
| Cited Reactivity | human |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag18940 Product name: Recombinant human SLCO1B3 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 11-48 aa of BC105597 Sequence: AESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIM Predict reactive species |
| Full Name | solute carrier organic anion transporter family, member 1B3 |
| Calculated Molecular Weight | 702 aa, 77 kDa |
| Observed Molecular Weight | 70-75 kDa |
| GenBank Accession Number | BC105597 |
| Gene Symbol | SLCO1B3 |
| Gene ID (NCBI) | 28234 |
| RRID | AB_3669405 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9NPD5 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| WB protocol for SLCO1B3/OATP1B3 antibody 22815-1-AP | Download protocol |
| human | WB,IHC Clin Epigenetics Decitabine regulates the resistance of HCC to sorafenib through demethylation Authors - Miao Zhang View Article |
| Citations | 2 |
| Dilutions | WB : 1:500-1:1000 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
SLCO1B3, also known as OATP8 or OATP1B3, is a member of Organic Anion Transporting Polypeptides (OATPs), which are sodium-independent organic anion transporters mediating the uptake of a wide range of structurally diverse endogenous and exogenous compounds, including bile acids, hormone conjugates, peptides, toxins, as well as a multitude of therapeutic drugs. SLCO1B3 is specifically expressed in liver under normal condition, while its expression has also been observed in cancer tissues like colon, prostate and pancreas. It corresponds to Oatp1b2 in mice, with the gene symbol Slco1b2. The mouse genome encodes only a single transporter gene in the OATP1B subfamily, because SLCO1B1 and SLCO1B3 arose in primates by gene duplication after divergence from rodents. The molecular mass of SLCO1B3 is highly dependent on the glycosylation modification (deglycosylated form of 65-75 kDa, fully-glycosylated form of 120 kDa). Protocols Product Specific Protocols WB protocol for SLCO1B3/OATP1B3 antibody 22815-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- A mechanistic study revealing that SLCO1B3 promotes gastric cancer development and metastasis through MAP1S expression downregulation.
Journal: BMC Cancer | Authors: Shihao Liang KD Validated | Species: human | Application: WB,IHC - Decitabine regulates the resistance of HCC to sorafenib through demethylation
Journal: Clin Epigenetics | Authors: Miao Zhang | Species: human | Application: WB,IHC
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