CoraLite® Plus 750 Anti-Mouse PD-1/CD279 Rabbit Recombinant Antibody CL750-98080 proteintech
$189.00
In stock
SKU
CL750-98080
| Catalog Number | CL750-98080 |
| Synonyms | CD279, PD-1, PD1, Pdc1, PD 1 |
| Host | Rabbit |
| Reactivity | mouse |
| Form | Liquid |
| Formulation | PBS, Azide |
| Applications | FC |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive FC detected in | anti-CD3/CD28 treated mouse splenocytes |
| Positive FC detected in | anti-CD3/CD28 treated mouse splenocytes |
| Flow Cytometry (FC) | FC : 0.25 ug per 10^6 cells in 100 μl suspension |
| Tested Reactivity | mouse |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | Recombinant protein Predict reactive species |
| Full Name | programmed cell death 1 |
| Calculated Molecular Weight | 32 kDa |
| GenBank Accession Number | NM_008798.2 |
| Gene Symbol | PD-1 |
| Gene ID (NCBI) | 18566 |
| RRID | AB_3749074 |
| Conjugate | CoraLite® Plus 750 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 755 nm / 780 nm |
| Excitation Laser | Red Laser (633 nm) |
| Purification Method | Protein A purification |
| UNIPROT ID | Q02242 |
| Storage Buffer | PBS with 0.09% sodium azide, pH 7.3. |
| Storage Conditions | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
| FC protocol for CL Plus 750 PD-1/CD279 antibody CL750-98080 | Download protocol |
| Citations | - |
| Isotype | IgG |
| Clonality | Recombinant |
| Clone Number | 240389B8 |
| Conjugation | CoraLite® Plus 750 |
Programmed cell death 1 (PD-1, also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain, a stalk, a transmembrane domain, and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) (PMID: 18173375). PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines (PMID: 20636820). Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function (PMID: 19426218). It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity (PMID: 22658127; 23169436). Protocols Product Specific Protocols FC protocol for CL Plus 750 PD-1/CD279 antibody CL750-98080 Download protocol Standard Protocols Click here to view our Standard Protocols
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