TRIM38 Polyclonal antibody 13405-1-AP proteintech
$149.00
In stock
SKU
13405-1-AP
| Catalog Number | 13405-1-AP |
| Synonyms | TRIM, RORET, RNF15, RING finger protein 15, EC:2.3.2.27 |
| Host | Rabbit |
| Reactivity | human and More (1) |
| Reactivity | human, mouse |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IHC, IF/ICC, IP, CoIP, ELISA |
| Applications | WB, IHC, IF/ICC, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | human liver tissue, HEK-293 cells, human colon tissue |
| Tested Applications — Positive IHC detected in | human liver tissue, human lung cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Tested Applications — Positive IF/ICC detected in | L02 cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:300-1:1000 |
| Recommended Dilutions — Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Recommended Dilutions — Immunofluorescence (IF)/ICC | IF/ICC : 1:50-1:500 |
| Positive WB detected in | human liver tissue, HEK-293 cells, human colon tissue |
| Positive IHC detected in | human liver tissue, human lung cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Positive IF/ICC detected in | L02 cells |
| Western Blot (WB) | WB : 1:300-1:1000 |
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Immunofluorescence (IF)/ICC | IF/ICC : 1:50-1:500 |
| Tested Reactivity | human |
| Cited Reactivity | human, mouse |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag3840 Product name: Recombinant human TRIM38 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 117-466 aa of BC026930 Sequence: RAPQHKGHTTALVEDVCQGYKEKLQKAVTKLKQLEDRCTEQKLSTAMRITKWKEKVQIQRQKIRSDFKNLQCFLHEEEKSYLWRLEKEEQQTLSRLRDYEAGLGLKSNELKSHILELEEKCQGSAQKLLQNVNDTLSRSWAVKLETSEAVSLELHTMCNVSKLYFDVKKMLRSHQVSVTLDPDTAHHELILSEDRRQVTRGYTQENQDTSSRRFTAFPCVLGCEGFTSGRRYFEVDVGEGTGWDLGVCMENVQRGTGMKQEPQSGFWTLRLCKKKGYVALTSPPTSLHLHEQPLLVGIFLDYEAGVVSFYNGNTGCHIFTFPKASFSDTLRPYFQVYQYSPLFLPPPGD Predict reactive species |
| Full Name | tripartite motif-containing 38 |
| Calculated Molecular Weight | 465 aa, 53 kDa |
| Observed Molecular Weight | 53 kDa |
| GenBank Accession Number | BC026930 |
| Gene Symbol | TRIM38 |
| Gene ID (NCBI) | 10475 |
| RRID | AB_2208307 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | O00635 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IF protocol for TRIM38 antibody 13405-1-AP | Download protocol |
| IHC protocol for TRIM38 antibody 13405-1-AP | Download protocol |
| WB protocol for TRIM38 antibody 13405-1-AP | Download protocol |
| human | WB,IHC,IF Exp Hematol Oncol Tetrahydromagnolol targets TRIM38 to mediate PANoptosis in cancer cells and has the potential for synergistic cancer therapy. Authors - Xiaoqing Gu KD Validated View Article |
| mouse | WB Int Immunopharmacol TRIM38 protects chondrocytes from IL-1β-induced apoptosis and degeneration via negatively modulating nuclear factor (NF)-κB signaling. Authors - Shouye Hu KD Validated View Article |
| Citations | 13 |
| Dilutions | WB : 1:300-1:1000 IHC : 1:50-1:500 IF/ICC : 1:50-1:500 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
The proinflammatory cytokines TNFα and IL-1β play central roles in many diseases, including infectious diseases, autoimmunity, and cancers. TRIM38 belongs to the TRIM protein family that is involved in various biological processes, including cell proliferation and apoptosis, innate immunity, and inflammatory response. It has been shown that TRIM38 acts as a suppressor in TOLL-like receptor (TLR)-mediated IFN-β induction by promoting degradation of TRAF6 and NAP1 through the ubiquitinproteasome system. (PMID:24434549) Protocols Product Specific Protocols IF protocol for TRIM38 antibody 13405-1-AP Download protocol IHC protocol for TRIM38 antibody 13405-1-AP Download protocol WB protocol for TRIM38 antibody 13405-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- Tertiary lymphoid structure stratifies glioma into three distinct tumor subtypes.
Journal: Aging (Albany NY) | Authors: Xingwang Zhou | Species: human | Application: IHC - E3 ubiquitin ligase TRIM38 regulates macrophage polarization to reduce hepatic inflammation by interacting with HSPA5
Journal: Int Immunopharmacol | Authors: Heeyoung Yang | Species: human | Application: IF - TRIM38 protects chondrocytes from IL-1β-induced apoptosis and degeneration via negatively modulating nuclear factor (NF)-κB signaling.
Journal: Int Immunopharmacol | Authors: Shouye Hu KD Validated | Species: mouse | Application: WB - Lactylation orchestrates ubiquitin-independent degradation of cGAS and promotes tumor growth
Journal: Cell Rep | Authors: Keqiang Rao KD Validated | Species: human | Application: WB - TRIM38 Inhibits Zika Virus by Upregulating RIG-I/MDA5 Pathway and Promoting Ubiquitin-Mediated Degradation of Viral NS3 Protein
Journal: Viruses | Authors: Jing He | Species: human | Application: WB - Tetrahydromagnolol targets TRIM38 to mediate PANoptosis in cancer cells and has the potential for synergistic cancer therapy.
Journal: Exp Hematol Oncol | Authors: Xiaoqing Gu KD Validated | Species: human | Application: WB,IHC,IF - Lactylation orchestrates ubiquitin-independent degradation of cGAS and promotes tumor growth
Journal: Cell Rep | Authors: Keqiang Rao | Species: human | Application: WB - E3 ubiquitin ligase TRIM38 regulates macrophage polarization to reduce hepatic inflammation by interacting with HSPA5
Journal: Int Immunopharmacol | Authors: Heeyoung Yang | Species: human | Application: IF - TRIM38 protects chondrocytes from IL-1β-induced apoptosis and degeneration via negatively modulating nuclear factor (NF)-κB signaling.
Journal: Int Immunopharmacol | Authors: Shouye Hu | Species: mouse | Application: WB - Tripartite motif 38 alleviates the pathological process of NAFLD/NASH by promoting TAB2 degradation
Journal: J Lipid Res | Authors: Xinxin Yao | Species: mouse | Application: WB,IHC - Di-(2-ethylhexyl)-phthalate disrupts mouse placental growth by regulating the cell cycle of mouse placental trophoblasts through the Trim38-p53 signaling axis
Journal: FASEB J | Authors: Yafei Guo | Species: mouse | Application: WB,IP,IF - TRIM38 Alleviates Ferroptosis in Heart Failure by Inactivating the TRAF6-p38 MAPK Pathway via Ubiquitinating Degradation of IRAK1.
Journal: Drug Dev Res | Authors: Yun Liu - TRIM38 Inhibits Zika Virus by Upregulating RIG-I/MDA5 Pathway and Promoting Ubiquitin-Mediated Degradation of Viral NS3 Protein
Journal: Viruses | Authors: Jing He | Species: human | Application: WB
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