Nectin-4/PVRL4 Monoclonal antibody 67721-1-Ig proteintech
$149.00
In stock
SKU
67721-1-Ig
| Catalog Number | 67721-1-Ig |
| Synonyms | Ig superfamily receptor LNIR, LNIR, nectin 4, Nectin-4, poliovirus receptor related 4, PRR4, PVRL4 |
| Host | Mouse |
| Reactivity | Human and More (1) |
| Reactivity | human |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IHC, ELISA |
| Applications | WB, ELISA |
| Host / Isotype | Mouse / IgG1 |
| Tested Applications — Positive WB detected in | human placenta tissue, A431 cells |
| Recommended Dilutions — Western Blot (WB) | WB : 1:500-1:3000 |
| Positive WB detected in | human placenta tissue, A431 cells |
| Western Blot (WB) | WB : 1:500-1:3000 |
| Tested Reactivity | Human |
| Cited Reactivity | human |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag14414 Product name: Recombinant human nectin 4 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 32-349 aa of BC010423 Sequence: GELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSAS Predict reactive species |
| Full Name | poliovirus receptor-related 4 |
| Calculated Molecular Weight | 510 aa, 55 kDa |
| Observed Molecular Weight | 43 kDa |
| GenBank Accession Number | BC010423 |
| Gene Symbol | Nectin-4 |
| Gene ID (NCBI) | 81607 |
| RRID | AB_2882908 |
| Conjugate | Unconjugated |
| Purification Method | Protein G purification |
| UNIPROT ID | Q96NY8 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| WB protocol for Nectin-4/PVRL4 antibody 67721-1-Ig | Download protocol |
| human | WB,IHC Cell Rep High-glucose-associated YTHDC1 lactylation reduces the sensitivity of bladder cancer to enfortumab vedotin therapy Authors - Zhuo Xing View Article |
| Citations | 1 |
| Dilutions | WB : 1:500-1:3000 |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Clone Number | 2D4B6 |
| Conjugation | Unconjugated |
Nectin-4, also known as PVRL4, is a type-I transmembrane glycoprotein that belongs to the nectin subfamily of immunoglobulin-like adhesion molecules that participate in Ca(2+)-independent cell-cell adhesion (PMID: 18703497). The extracellular domain of Nectin-4, which contains three immunoglobulin-like domains (V and two C2-type domains, VCC), can be proteolytically cleaved to release a soluble form. Nectin-4 interacts with afadin via its carboxyl-terminal cytoplasmic sequence and trans-interacts with nectin-1/PRR1 through V domain interaction (PMID: 11544254). It acts as a receptor for measles virus (PMID: 22048310). Nectin-4 is overexpressed in multiple human malignancies and the aberrant expression is correlated with cancer progression and poor prognostic (PMID: 35131876). Nectin-4 can be detected as a soluble form of 43 kDa and a transmembrane form of 66 kDa (PMID: 15784625). Protocols Product Specific Protocols WB protocol for Nectin-4/PVRL4 antibody 67721-1-Ig Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- High-glucose-associated YTHDC1 lactylation reduces the sensitivity of bladder cancer to enfortumab vedotin therapy
Journal: Cell Rep | Authors: Zhuo Xing | Species: human | Application: WB,IHC
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