SARS-CoV-2 S protein (944-1214 aa) Polyclonal antibody 28867-1-AP proteintech
$149.00
In stock
SKU
28867-1-AP
| Catalog Number | 28867-1-AP |
| Synonyms | COVID-19 RBD, RBD, Spike, spike protein, S protein |
| Host | Rabbit |
| Reactivity | virus and More (3) |
| Reactivity | virus, human, monkey, hamster |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IHC, IF, ELISA |
| Applications | ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive ELISA detected in | Recombinant protein |
| Positive ELISA detected in | Recombinant protein |
| Enzyme-linked Immunosorbent Assay (ELISA) | ELISA : |
| Tested Reactivity | virus |
| Cited Reactivity | human, monkey, hamster |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag30685 Product name: Recombinant virus spike protein protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 944-1214 aa of NC_045512 Sequence: ALGKLQDVVN QNAQALNTLV KQLSSNFGAI SSVLNDILSR LDKVEAEVQI DRLITGRLQS LQTYVTQQLI RAAEIRASAN LAATKMSECV LGQSKRVDFC GKGYHLMSFP QSAPHGVVFL HVTYVPAQEK NFTTAPAICH DGKAHFPREG VFVSNGTHWF VTQRNFYEPQ IITTDNTFVS GNCDVVIGIV NNTVYDPLQP ELDSFKEELD KYFKNHTSPD VDLGDISGIN ASVVNIQKEI DRLNEVAKNL NESLIDLQEL GKYEQYIKWP W Predict reactive species |
| Full Name | SARS-CoV-2 Spike Protein |
| Calculated Molecular Weight | 141 kDa |
| GenBank Accession Number | NC_045512 |
| Gene Symbol | SARS-COV-2 |
| Gene ID (NCBI) | 43740568 |
| RRID | AB_2881223 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P0DTC2 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| monkey,hamster | IF Nat Biomed Eng High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2 Authors - Charles W F Chan View Article |
| human | IF Int J Mol Sci Modulation of NBAS-Related Functions in the Early Response to SARS-CoV-2 Infection Authors - Valentina Granata View Article |
| Citations | 14 |
| Dilutions | ELISA : |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
Coronaviruses (CoVs) infect human and animals and cause varieties of diseases, including respiratory, enteric, renal, and neurological diseases. CoV uses its spike protein to recognize ACE2 as its receptors and mediate membrane fusion and virus entry into host cells(PMID: 32221306). Each monomer of trimeric S protein is about 180 kDa, and contains two subunits, S1 and S2,S1 recognizes and binds to host receptors, and subsequent conformational changes in S2 facilitate fusion between the viral envelope and the host cell membrane(PMID: 19198616). Although the amino acid sequences of the S-glycoprotein were found to be different between the various HCoV, the structures showed high similarity, but the best 3D structural overlap shared by SARS-CoV and SARS-CoV-2, consistent with the shared ACE2 predicted receptor (PMID: 32522207). The spike protein of CoVs can be a target for vaccine and therapeutic development (PMID: 19198616). This antibody detects the spike protein of SARS and SARS-COV-2.
Publications
- High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2
Journal: Nat Biomed Eng | Authors: Charles W F Chan | Species: monkey,hamster | Application: IF - Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules.
Journal: Nat Immunol | Authors: Matteo Stravalaci | Species: human | Application: IF - Essential role of TMPRSS2 in SARS-CoV-2 infection in murine airways
Journal: Nat Commun | Authors: Naoko Iwata-Yoshikawa | Species: human | Application: IF - Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus
Journal: bioRxiv | Authors: Qiwang Xiang | Application: WB - Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2.
Journal: Cell Rep | Authors: Xiaojuan Zhou | Application: IF - Modulation of NBAS-Related Functions in the Early Response to SARS-CoV-2 Infection
Journal: Int J Mol Sci | Authors: Valentina Granata | Species: human | Application: IF - Modulation of NBAS-Related Functions in the Early Response to SARS-CoV-2 Infection
Journal: Int J Mol Sci | Authors: Valentina Granata | Species: human | Application: IF - Exosomes derived from syncytia induced by SARS-2-S promote the proliferation and metastasis of hepatocellular carcinoma cells
Journal: Front Cell Infect Microbiol | Authors: Huilong Li | Application: IF - CD81 fusion alters SARS-CoV-2 Spike trafficking
Journal: mBio | Authors: Allaura S Cone | Application: WB - Nasal mucus-derived KLK13 restricts SARS-CoV-2 infection via proteolytic cleavage of spike.
Journal: mBio | Authors: Wenying Cao | Species: human | Application: WB,IF - The respective roles of TMPRSS2 and cathepsins for SARS-CoV-2 infection in human respiratory organoids
Journal: J Virol | Authors: Masatoshi Kakizaki | Species: human | Application: IF - Hydrophobic Alpha-Helical Short Peptides in Overlapping Reading Frames of the Coronavirus Genome
Journal: Pathogens | Authors: Takashi Okura | Application: IF - Ubiquitin Ligase ITCH Regulates Life Cycle of SARS-CoV-2 Virus
Journal: bioRxiv | Authors: Qiwang Xiang | Application: WB - Ubiquitin ligase ITCH regulates life cycle of SARS-CoV-2 virus.
Journal: Elife | Authors: Qiwang Xiang | Species: human | Application: WB
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