AVEN Polyclonal antibody 25846-1-AP proteintech
$149.00
In stock
SKU
25846-1-AP
| Catalog Number | 25846-1-AP |
| Synonyms | Cell death regulator Aven, PDCD12 |
| Host | Rabbit |
| Reactivity | human, mouse, rat |
| Form | Liquid |
| Formulation | PBS, Azide, Glycerol |
| Applications | WB, IHC, ELISA |
| Host / Isotype | Rabbit / IgG |
| Tested Applications — Positive WB detected in | MCF-7 cells, K-562 cells |
| Tested Applications — Positive IHC detected in | human colon tissue, human placenta tissue, human testis tissue, mouse cerebellum tissue, mouse testis tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Recommended Dilutions — Western Blot (WB) | WB : 1:500-1:2000 |
| Recommended Dilutions — Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Positive WB detected in | MCF-7 cells, K-562 cells |
| Positive IHC detected in | human colon tissue, human placenta tissue, human testis tissue, mouse cerebellum tissue, mouse testis tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
| Western Blot (WB) | WB : 1:500-1:2000 |
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| Tested Reactivity | human, mouse, rat |
| Cited Reactivity | human |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CatNo: Ag23020 Product name: Recombinant human AVEN protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-362 aa of BC010488 Sequence: MQAERGARGGRGRRPGRGRPGGDRHSERPGAAAAVARGGGGGGGGDGGGRRGRGRGRGFRGARGGRGGGGAPRGSRREPGGWGAGASAPVEDDSDAETYGEENDEQGNYSKRKIVSNWDRYQDIEKEVNNESGESQRGTDFSVLLSSAGDSFSQFRFAEEKEWDSEASCPKQNSAFYVDSELLVRALQELPLCLRLNVAAELVQGTVPLEVPQVKPKRTDDGKGLGMQLKGPLGPGGRGPIFELKSVAAGCPVLLGKDNPSPGPSRDSQKPTSPLQSAGDHLEEELDLLLNLDAPIKEGDNILPDQTSQDLKSKEDGEVVQEEEVCAKPSVTEEKNMEPEQPSTSKNVTEEELEDWLDSMIS Predict reactive species |
| Full Name | apoptosis, caspase activation inhibitor |
| Calculated Molecular Weight | 39 kDa |
| Observed Molecular Weight | 50 kDa |
| GenBank Accession Number | BC010488 |
| Gene Symbol | AVEN |
| Gene ID (NCBI) | 57099 |
| RRID | AB_2880266 |
| Conjugate | Unconjugated |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9NQS1 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA. |
| IHC protocol for AVEN antibody 25846-1-AP | Download protocol |
| WB protocol for AVEN antibody 25846-1-AP | Download protocol |
| human | WB Open Med (Wars) Tanshinone IIA reverses oxaliplatin resistance in colorectal cancer through microRNA-30b-5p/AVEN axis. Authors - Tingrui Ge View Article |
| Citations | 2 |
| Dilutions | WB : 1:500-1:2000 IHC : 1:50-1:500 |
| Isotype | IgG |
| Clonality | Polyclonal |
| Clone Number | - |
| Conjugation | Unconjugated |
AVEN (Apoptosis caspase activation inhibitor) is known to play a role in male and female germ cell development. AVEN protein has also been shown to inhibit the mitochondrial apoptosis pathway by binding to and inhibiting the self-association of proapoptotic APAF-1, as well as binding to and enhancing antiapoptotic BCL-xL activity. AVEN has also recently been shown to function as an activator of the cell cycle-regulating ATM kinase in the DNA damage response pathway. Molecular weight of this protein detected by WB is 50 kDa (PMID: 22751129). Protocols Product Specific Protocols IHC protocol for AVEN antibody 25846-1-AP Download protocol WB protocol for AVEN antibody 25846-1-AP Download protocol Standard Protocols Click here to view our Standard Protocols
Publications
- Integrative proteomics and m6A microarray analyses of the signatures induced by METTL3 reveals prognostically significant in gastric cancer by affecting cellular metabolism
Journal: Front Oncol | Authors: Guisen Peng | Species: human | Application: WB - Tanshinone IIA reverses oxaliplatin resistance in colorectal cancer through microRNA-30b-5p/AVEN axis.
Journal: Open Med (Wars) | Authors: Tingrui Ge | Species: human | Application: WB
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