Product Information
| Protein full name | Signal transducing adapter molecule 2 |
| Synonyms | STAM-2, Hrs-binding protein, Stam2, Hbp, STAM2A, STAM2B, HSE1 homolog |
| Uniprot ID | O88811 |
| Immunogen | Recombinant protein corresponding to Mouse STAM2 |
| Isotype | IgG |
| Predicted MW./Observed MW. | 57 kDa / 70 kDa |
| Purity | Affinity purification |
Applications
| Applications: WB | Species: Mouse |
| Dilution: 1: 1000-1: 2000 | Positive Tissue: stomach, liver |
Background
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
Images
WB analysis of STAM2(GB113020). Sample: Protein treated by RIPA Lysis Buffer (G2002). Blocking buffer: 3% Nonfat dry milk (GC310001) in TBST, RT, 1h. Primary antibody: 1: 2000, 4℃ overnight. Secondary antibody: HRP conjugated Goat Anti-Rabbit lgG (H+L) (GB23303), 1: 5000, RT, 1h.
Storage
| Storage | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).