Recombinant Anti-CD48 Antibody (APC), Rabbit Monoclonal sinobiological 80286-R002-A

$157.00
In stock
SKU
80286-R002-A
Catalog No.SizePrice (USD)
80286-R002-A-2525 Tests$162.92
80286-R002-A-100100 Tests$325.84

General Information

Product nameRecombinant Anti-CD48 Antibody (APC), Rabbit Monoclonal
Validated applicationsFCM (FAQ Protocol)
Species reactivityReacts with: Rat
SpecificityRat CD48
ImmunogenRecombinant Rat CD48/Blast-1 Protein (Catalog#80286-R08H)
PreparationThis antibody was obtained from a rabbit immunized with purified, recombinant Rat CD48/Blast-1 (rR CD48/Blast-1; Catalog#80286-R08H; P10252; Met1-Arg216) and conjugated with APC under optimum conditions, the unreacted APC was removed.
SourceMonoclonal Rabbit IgG Clone #002
PurificationProtein A
FormulationPBS solution containing 0.5% BSA and 0.09% sodium azide
Concentration10 μl/Test, 0.1 mg/ml
ConjugateAPC
FormLiquid
ShippingThis antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
StorageThis antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Synonyms: Anti-Bcm-1 Antibody; Anti-Cd48 Antibody; Anti-SLAMF2 Antibody

Image / Experimental Information

Image 1 DescriptionFlow cytometric analysis of Rat CD48 expression on SD rat splenocytes. Cells were stained with APC-conjugated anti-Rat CD48. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Image 1 Alt TextRat CD48/Blast-1 Flow Cytometry (FC) 15353
Image 1 URLSource image

Background Information

Full NameCD48 molecule
DescriptionCluster of Differentiation 48 (CD48), also known as SLAMF2, BCM-1 and BLAST-1, is a GPI-linked protein belonging to the CD2 subfamily of immunoglobulin superfamily molecules. CD2 and 2B4 (CD244) are known ligands for CD48. CD48 protein is expressed on most lineage-committed hematopoietic cells but not on hematopoietic stem cells or multipotent hematopoietic progenitors. CD48 protein performs biological functions in a variety processes including adhesion, pathogen recognition, cellular activation, and cytokine regulation, and emerges as a critical effector molecule in immune responses.
Research Areas
  • Cancer Drug Targets
Tags
  • Cancer Immunotherapy
  • Co-inhibitory Immune Checkpoint Targets
  • Immune Checkpoint
  • Immune Checkpoint Detection: Antibodies
  • Immune Checkpoint Detection: ELISA Antibodies
  • Immune Checkpoint Detection: FCM Antibodies
  • Immune Checkpoint Detection: ICC Antibodies
  • Immune Checkpoint Detection: IHC Antibodies
  • Immune Checkpoint Detection: IP Antibodies
  • Immune Checkpoint Detection: WB Antibodies
  • Immune Checkpoint Proteins
  • Immune Checkpoint Targets
  • Immunotherapy
  • Targeted Therapy
References
  1. Messmer B, et al. (2006) CD48 stimulation by 2B4 (CD244)-expressing targets activates human NK cells. J Immunol. 176(8): 4646-50
  2. Milstein O, et al. (2008) Nanoscale increases in CD2-CD48-mediated intermembrane spacing decrease adhesion and reorganize the immunological synapse. J Biol Chem. 283(49): 34414-22.

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