| Catalog No. | Size | Price (USD) |
| 80299-T52-50 | 50 µL | $147.96 |
| 80299-T52-100 | 100 µL | $251.64 |
| 80299-T52-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-CD59 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol), ELISA (FAQ Protocol), IP (FAQ Protocol) |
| Species reactivity | Reacts with: Rat |
| Specificity | Rat CD59 |
| Immunogen | Recombinant Rat CD59 Protein (Catalog#80299-R08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Rat CD59 (rR CD59; Catalog#80299-R08H; P27274; Met1-Asn100). CD59 specific IgG was purified by Rat CD59 affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-Cd59 Antibody
Image / Experimental Information
| Image 1 Description | Anti-CD59 rabbit polyclonal antibody at 1:500 dilution Lane A: Rat Spleen tissue lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:14 kDa Observed band size:14 kDa |
| Image 1 Alt Text | Rat CD59 Western blot (WB) 20221 |
| Image 1 URL | Source image |
| Image 2 Description | Anti-CD59 rabbit polyclonal antibody at 1:500 dilution Lane A: Rat Spleen tissue lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:14 kDa Observed band size:14 kDa |
| Image 2 Alt Text | Rat CD59 Immunoprecipitation(IP) 20222 |
| Image 2 URL | Source image |
Background Information
| Full Name | CD59 molecule |
| Description | CD59 glycoprotein, also known as 2 kDa homologous restriction factor, HRF2, MAC-inhibitory protein, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIC11, MIRL and CD59, is a cell membrane protein which contains one UPAR/Ly6 domain. CD59 is a small, highly glycosylated, GPI-linked protein, with a wide expression profile. The soluble form of CD59 from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D). |
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| References |
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