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Anti-CEACAM-1/CD66a Antibody, Rabbit Polyclonal sinobiological 80224-T60

Anti-CEACAM-1/CD66a Antibody, Rabbit Polyclonal sinobiological 80224-T60

Name: Anti-CEACAM-1/CD66a Antibody, Rabbit Polyclonal sinobiological 80224-T60
SKU: 80224-T60
Price: 243 USD
Availability: InStock

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$243.00

In stock

SKU

80224-T60

Catalog No.	Size	Price (USD)
80224-T60-100	100 µL	$251.64

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Product introduction

General Information

Product name	Anti-CEACAM-1/CD66a Antibody, Rabbit Polyclonal
Validated applications	WB (FAQ Protocol), ELISA (FAQ Protocol), IHC-P (FAQ Protocol), IP (FAQ Protocol)
Species reactivity	Reacts with: Rat
Specificity	Rat CEACAM-1/CD66a
Immunogen	Recombinant Rat CEACAM-1/CD66a Protein (Catalog#80224-R08H)
Preparation	Produced in rabbits immunized with purified, recombinant Rat CEACAM-1/CD66a (rR CEACAM-1/CD66a; Catalog#80224-R08H; NP_001029032.1; Met1-Ser422). CEACAM-1/CD66a specific IgG was purified by Rat CEACAM-1/CD66a affinity chromatography.
Source	Polyclonal Rabbit IgG
Purification	Protein A & Antigen Affinity
Formulation	0.2 μm filtered solution in PBS
Conjugate	Unconjugated
Form	Liquid
Shipping	This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Synonyms: Anti-Bgp Antibody; Anti-BGPR Antibody; Anti-Ccam1 Antibody; Anti-CD66a Antibody; Anti-Ceacam1 Antibody

Image / Experimental Information

Image 1 Description	Anti-CEACAM-1/CD66a rabbit polyclonal antibody at 1:500 dilution Lane A: Rat liver tissue lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 57 kDa Observed band size: 100-180 kDa
Image 1 Alt Text	Rat CEACAM-1/CD66a Western blot (WB) 43402
Image 1 URL	Source image
Image 2 Description	Anti-CEACAM-1/CD66a rabbit polyclonal antibody at 1:500 dilution Lane A: Rat liver tissue lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 57 kDa Observed band size: 100-180 kDa
Image 2 Alt Text	Rat CEACAM-1/CD66a Immunohistochemistry(IHC) 43403
Image 2 URL	Source image
Image 3 Description	Anti-CEACAM-1/CD66a rabbit polyclonal antibody at 1:500 dilution Lane A: Rat liver tissue lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 57 kDa Observed band size: 100-180 kDa
Image 3 Alt Text	Rat CEACAM-1/CD66a Immunohistochemistry(IHC) 43404
Image 3 URL	Source image
Image 4 Description	Anti-CEACAM-1/CD66a rabbit polyclonal antibody at 1:500 dilution Lane A: Rat liver tissue lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 57 kDa Observed band size: 100-180 kDa
Image 4 Alt Text	Rat CEACAM-1/CD66a Immunohistochemistry(IHC) 43405
Image 4 URL	Source image
Image 5 Description	Anti-CEACAM-1/CD66a rabbit polyclonal antibody at 1:500 dilution Lane A: Rat liver tissue lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 57 kDa Observed band size: 100-180 kDa
Image 5 Alt Text	Rat CEACAM-1/CD66a Immunoprecipitation(IP) 43406
Image 5 URL	Source image

Background Information

Full Name	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
Description	The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. CEACAM1, also known as biliary glycoprotein I (BGP I) and CD66a, is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. CEACAM1 is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.
Research Areas	Cancer Drug Targets ITIM/ITAM Immunoreceptors and Related Molecules
Tags	Cancer Immunotherapy Co-inhibitory Immune Checkpoint Targets Immune Checkpoint Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: FCM Antibodies Immune Checkpoint Detection: ICC Antibodies Immune Checkpoint Detection: IHC Antibodies Immune Checkpoint Detection: WB Antibodies Immune Checkpoint Proteins Immune Checkpoint Targets Immunotherapy Targeted Therapy
References	Gray-Owen SD, et al. (2006) CEACAM1: contact-dependent control of immunity. Nat Rev Immunol. 6(6): 433-46. Gu A, et al. (2009) Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. Exp Cell Res. 315(10): 1668-82. Wong C, et al. (2009) CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo. Blood. 113(8): 1818-28.