| Catalog No. | Size | Price (USD) |
| 102003-T32-50 | 50 µL | $147.96 |
| 102003-T32-100 | 100 µL | $251.64 |
| 102003-T32-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-LAIR1 Antibody, Rabbit Polyclonal |
| Validated applications | WB (FAQ Protocol) |
| Species reactivity | Reacts with: Rat |
| Specificity | Rat LAIR1 |
| Immunogen | A synthetic peptide corresponding to the N-terminus of the Rat LAIR1/LAIR-1/CD305 |
| Preparation | Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Rat LAIR1/LAIR-1/CD305, and purified by antigen affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-Lair1 Antibody
Image / Experimental Information
| Image 1 Description | Anti-LAIR1 rabbit polyclonal antibody at 1:500 dilution. Lane A: mouse liver tissue lysate Lysates/proteins at 30 μg per lane. Secondary Goat Anti- Rabbit IgG H&L (Dylight 800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size:31 kDa Observed band size:31 kDa |
| Image 1 Alt Text | Human LAIR1/LAIR-1/CD305 Western blot (WB) 15857 |
| Image 1 URL | Source image |
Background Information
| Full Name | leukocyte-associated immunoglobulin-like receptor 1 |
| Description | Leukocyte-associated Ig-like receptor-1 (LAIR1) is a surface molecule expressed on human mononuclear leukocytes that functions as an inhibitory receptor on human NK cells. In addition to NK cells, LAIR1 is expressed on T cells, B cells, macrophages, and dendritic cells. It is predicted to mediate inhibitory functions based on the presence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic domain. Cross-linking of LAIR1 on human T cell clones results in inhibition of cytotoxicity only in T cell clones that lack CD28 and can spontaneously lyse certain targets in vitro. Moreover, the cytolytic activity of freshly isolated T cells, which is thought to be mainly due to "effector" T cells, can be inhibited by anti-LAIR1 mAb. Thus, LAIR1 functions as an inhibitory receptor not only on NK cells but also on human T cells. This indicates that LAIR1 provides a mechanism of regulation of effector T cells and may play a role in the inhibition of unwanted bystander responses mediated by Ag-specific T cells. |
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