| Catalog No. | Size | Price (USD) |
| 12283-MM42-50 | 50 µL | $147.96 |
| 12283-MM42-100 | 100 µL | $251.64 |
| 12283-MM42-200 | 200 µL | $355.32 |
General Information
| Product name | Anti-CD47 Antibody, Mouse Monoclonal |
| Validated applications | IHC-P (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human CD47 |
| Immunogen | Recombinant Human CD47 Protein (Catalog#12283-H08H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD47 (rh CD47; Catalog#12283-H08H; NP_942088.1; Met1-Pro139). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Source | Monoclonal Mouse IgG1 Clone #42 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-IAP Antibody; Anti-MER6 Antibody; Anti-OA3 Antibody
Image / Experimental Information
| Image 1 Description | Immunochemical staining of human CD47 in human lung cancer with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. |
| Image 1 Alt Text | Human CD47 Immunohistochemistry(IHC) 34912 |
| Image 1 URL | Source image |
| Image 2 Description | Immunochemical staining of human CD47 in human lung cancer with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. |
| Image 2 Alt Text | Human CD47 Immunohistochemistry(IHC) 34913 |
| Image 2 URL | Source image |
Background Information
| Full Name | CD47 molecule |
| Description | CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and is a receptor for the C-terminal cell binding domain of thrombospondin. It may play a role in membrane transport and signal transduction. CD47 is also a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. CD47 may play a role in membrane transport and/or integrin dependent signal transduction. It may prevent premature elimination of red blood cells. It also may be involved in membrane permeability changes induced following virus infection. By acting as an adhesion receptor for THBS1 on platelets, CD47 plays a role in both cell adhesion and in the modulation of integrins. It also plays an important role in memory formation and synaptic plasticity in the hippocampus. |
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