Anti-IL-2R beta/CD122 Antibody, Rabbit Polyclonal sinobiological 50792-T16
$243.00
In stock
SKU
50792-T16
| Catalog No. | Size | Price (USD) |
| 50792-T16-100 | 100 µL | $251.64 |
General Information
| Product name | Anti-IL-2R beta/CD122 Antibody, Rabbit Polyclonal |
| Validated applications | ELISA (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse IL-2R beta/CD122 |
| Immunogen | Recombinant Mouse CD122/IL2RB Protein (Catalog#50792-M08H) |
| Preparation | Produced in rabbits immunized with purified, recombinant Mouse CD122/IL2RB (rM CD122/IL2RB; Catalog#50792-M08H; P16297; Met1-Glu240). CD122/IL2RB specific IgG was purified by Mouse CD122/IL2RB affinity chromatography. |
| Source | Polyclonal Rabbit IgG |
| Purification | Protein A & Antigen Affinity |
| Formulation | 0.2 μm filtered solution in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-CD122 Antibody; Anti-IL-15Rbeta Antibody; Anti-Il-2/15Rbeta Antibody; Anti-Il-2Rbeta Antibody; Anti-IL15Rbeta Antibody; Anti-Il2rb Antibody; Anti-p70 Antibody
Background Information
| Full Name | interleukin 2 receptor, beta |
| Description | Interleukin-2 receptor (IL-2R) also known as High-affinity IL-2 receptor subunit beta, IL-2 receptor subunit beta, and IL-2RB, is involved in T cell-mediated immune responses. CD122/IL-2RB is present in 3 forms concerning the ability to bind interleukin 2. The low-affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high-affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high-affinity forms of CD122/IL-2RB are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. CD122/IL-2RB expression was restricted to the earliest B220+ cells (CD43+CD24-; prepro B cells; fraction A) that proliferate vigorously to IL-2 in the absence of any stromal cells, but not to IL-15. The high-affinity form of this receptor is expressed on activated T lymphocytes, activated B lymphocytes, and activated macrophages. CD122/IL-2RB plays a role in regulating normal lymphocyte development. |
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