Human c-MET/HGFR ELISA Kit sinobiological KIT10692

$400.00
In stock
SKU
KIT10692
Catalog No.SizePrice (USD)
KIT10692-11 Kit (96 Tests)$414.71

General Information

Product nameHuman c-MET/HGFR ELISA Kit
SpecificityThis assay recognizes both recombinant and natural Human HGFR.
ConjugateHRP
ShippingThis ELISA Kit is shipped at ambient temperature.
StorageUnopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA
Assay typeSolid Phase Sandwich ELISA (quantitative)
Sample typeSerum,Plasma
Sensitivity45.71 pg/mL
Assay range187.5-12000 pg/mL
Materials provided1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution
Product overviewThis Human c-MET/HGFR ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Human c-MET/HGFR protein in Serum,Plasma . It contains recombinant Human c-MET/HGFR, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.
InterferencePreparations of the factors listed below at 50 ng/mL in a mid-range recombinant human HGFR control were assayed for interference. No significant interference was observed.

Synonyms: AUTS9 ELISA Kit, Human; c-Met ELISA Kit, Human; DA11 ELISA Kit, Human; DFNB97 ELISA Kit, Human; HGFR ELISA Kit, Human; RCCP2 ELISA Kit, Human

Image / Experimental Information

Image 1 DescriptionThis standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Image 1 Alt TextHuman c-MET ELISA Kit Standard Curve 20744
Image 1 URLSource image
Image 2 DescriptionThis standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Image 2 Alt TextHuman c-MET ELISA Kit Specificity 20748
Image 2 URLSource image

Background Information

Full NameMET proto-oncogene, receptor tyrosine kinase
DescriptionHepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair, or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.
Research Areas
  • Cancer Drug Targets
  • Receptor Tyrosine Kinases (RTKs)
Tags
  • Cancer Immunotherapy
  • Immune Checkpoint
  • Immunotherapy
  • Targeted Therapy
References
  1. McGill GG, et al. (2006) c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem. 281(15): 10365-73.
  2. Garcia S, et al. (2007) c-Met overexpression in inflammatory breast carcinomas: automated quantification on tissue microarrays. British journal of cancer. 96(2): 329-35.
  3. Socoteanu MP, et al. (2008) c-Met targeted therapy of cholangiocarcinoma. World J Gastroenterol. 14(19): 2990-4.
  4. Kong DS, et al. (2009) Prognostic significance of c-Met expression in glioblastomas. Cancer. 115(1): 140-8.

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