| Catalog No. | Size | Price (USD) |
| 15673-R013-200 | 200 µg | $296.22 |
| 15673-R013-500 | 500 µg | $444.33 |
General Information
| Product name | IL-5/IL5/Interleukin 5 Neutralizing Antibody |
| Validated applications | ELISA(Det) (FAQ Protocol), Neutralization |
| Species reactivity | Reacts with: Human |
| Specificity | Human IL-5 Has cross-reactivity in ELISA with Mouse IL5 (Catalog# 51068-M08B) |
| Immunogen | Recombinant Human IL-5/IL5/Interleukin 5 protein (Catalog#15673-HNCE) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Human IL-5/IL5/Interleukin 5 (rh L-5/IL5/Interleukin 5; Ile20-Ser134; P05113; Catalog#15673-HNCE). |
| Source | Monoclonal Rabbit IgG Clone #R013 |
| Purification | Protein A |
| Formulation | 0.2 μm filtered solution in Histidine and Arginine buffer containing 120mM NaCl, 0.02% Tween 80, pH6.0 |
| Conjugate | Unconjugated |
| Endotoxin | < 3 EU/mg |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
Synonyms: Anti-EDF Antibody; Anti-IL-5 Antibody; Anti-TRF Antibody
Image / Experimental Information
| Image 1 Description | Cell Proliferation Induced by IL‑5 and Neutralization by Human IL5 Antibody. Human IL5 (Catalog#15673-HNCE ) stimulates proliferation in the TF‑1 human erythroleukemic cell line . Proliferation elicited by Recombinant Human IL5 (1.25 ng/mL) is neutralized by increasing concentrations of Rabbit Anti-Human IL‑5 Monoclonal Antibody (Catalog#15673-R013). The ND50 is typically 2-8 ng/mL . |
| Image 1 Alt Text | Human IL-5/IL5 / Interleukin 5 Blocking/Neutralization (B/N) 17120 |
| Image 1 URL | Source image |
Background Information
| Full Name | interleukin 5 |
| Description | Interleukin 5 (IL-5) is a member of the interleukin family with a length of 115 amino acids. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes) and has been found in a wide variety of body cells. Interleukin 5 or IL-5 is produced by T helper-2 cells and mast cells. It helps to stimulate B cell growth and increase immunoglobulin secretion and is considered a key mediator in eosinophil activation. Interleukin 5 (IL-5) has long been associated with several allergic diseases, including allergic rhinitis and asthma. Growth in the number of circulating, airway tissue, and induced sputum eosinophils have been observed in patients with these diseases. IL-5 also had something with the terminally differentiated granulocyte eosinophils. IL-5 was originally found as an eosinophil colony-stimulating factor. It has been proved to be a major regulator of eosinophil accumulation in tissues and can modulate eosinophil behavior at every stage from maturation to survival. |
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