| Catalog No. | Size | Price (USD) |
| 50724-R108-A-25 | 25 Tests | $103.68 |
| 50724-R108-A-100 | 100 Tests | $222.17 |
General Information
| Product name | Recombinant Anti-CD59a Antibody (APC), Rabbit Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Mouse |
| Specificity | Mouse CD59a |
| Immunogen | Recombinant Mouse CD59a Protein (Catalog#50724-M08H) |
| Preparation | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD59a (rM CD59a; Catalog#50724-M08H; NP_001104530.1; Met1-Lys95) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Source | Monoclonal Rabbit IgG Clone #108 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Concentration | 5 μl/Test, 0.1 mg/ml |
| Conjugate | APC |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! |
Synonyms: Anti-Cd59 Antibody; Anti-Cd59a Antibody; Anti-MAC-IP Antibody; Anti-MACIF Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of Mouse CD59a expression on BABL/c bone marrow erythroid cells. Cells were stained with APC-conjugated anti-Mouse CD59a. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of erythroid cells. |
| Image 1 Alt Text | Mouse CD59a Flow Cytometry (FC) 33908 |
| Image 1 URL | Source image |
Background Information
| Full Name | CD59a antigen |
| Description | Protectin, a complement regulatory protein, also known as CD59, or MIRL (membrane inhibitor of reactive lysis) is a small protein that inhibits the complement membrane attack complex by binding C5b678 and preventing C9 from binding and polymerizing. The amino-terminal 25 amino acids represented a typical signal peptide sequence and the carboxy-terminal hydrophobic amino acids were characteristic for phosphatidylinositol-anchored proteins. It was found that the CD59/Protectin antigen is a small protein sometimes associated with larger components (45 and 80 kD) in urine. CD59/Protectin antigen was released from the surface of transfected COS cells by phosphatidylinositol-specific phospholipase C, demonstrating that it is attached to the cell membrane by means of a glycolipid anchor; it is therefore likely to be absent from the surface of affected erythrocytes in the disease paroxysmal nocturnal hemoglobinuria. |
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