Mouse DLL4 ELISA Kit sinobiological KIT50640
$714.00
In stock
SKU
KIT50640
| Catalog No. | Size | Price (USD) |
| KIT50640-1 | 1 Kit (96 Tests) | $740.55 |
General Information
| Product name | Mouse DLL4 ELISA Kit |
| Specificity | This assay recognizes both recombinant and natural Mouse DLL4. |
| Conjugate | HRP |
| Shipping | This ELISA Kit is shipped at ambient temperature. |
| Storage | Unopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA |
| Assay type | Solid Phase Sandwich ELISA (quantitative) |
| Sample type | Serum |
| Sensitivity | 5.51 pg/mL |
| Assay range | 46.87-3000 pg/mL |
| Materials provided | 1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution |
| Product overview | This Mouse DLL4 ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Mouse DLL4 protein in Serum . It contains recombinant Mouse DLL4, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use. |
Synonyms: Delta4 ELISA Kit, Mouse; Dll4 ELISA Kit, Mouse
Image / Experimental Information
| Image 1 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 1 Alt Text | Mouse DLL4/Delta-like 4 ELISA Kit Standard Curve 135 |
| Image 1 URL | Source image |
| Image 2 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 2 Alt Text | Mouse DLL4/Delta-like 4 ELISA Kit Specificity 184 |
| Image 2 URL | Source image |
Background Information
| Full Name | delta-like 4 (Drosophila) |
| Description | Delta-like protein 4 (DLL4, Delta4), a type I membrane-bound Notch ligand, is one of five known Notch ligands in mammals and interacts predominantly with Notch 1, which has a key role in vascular development. Recent studies yield substantial insights into the role of DLL4 in angiogenesis. DLL4 is induced by vascular endothelial growth factor (VEGF) and acts downstream of VEGF as a 'brake' on VEGF-induced vessel growth, forming an autoregulatory negative feedback loop inactivating VEGF. DLL4 is downstream of VEGF signaling and its activation triggers a negative feedback that restrains the effects of VEGF. Attenuation of DLL4/Notch signaling results in chaotic vascular network with excessive branching and sprouting. DLL4 is widely distributed in tissues other than vessels including many malignancies. Furthermore, the molecule is internalized on binding its receptor and often transported to the nucleus. In pathological conditions, such as cancer, DLL4 is up-regulated strongly in the tumour vasculature. Blockade of DLL4-mediated Notch signaling strikingly increases nonproductive angiogenesis, but significantly inhibits tumor growth in preclinical mouse models. In preclinical studies, blocking of DLL4/Notch signaling is associated with a paradoxical increase in tumor vessel density, yet causes marked growth inhibition due to functionally defective vasculature. Thus, DLL4 blockade holds promise as an additional strategy for angiogenesis-based cancer therapy. |
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