Rat IL1R2 ELISA Kit sinobiological KIT80196

$714.00
In stock
SKU
KIT80196
Catalog No.SizePrice (USD)
KIT80196-11 Kit (96 Tests)$740.55

General Information

Product nameRat IL1R2 ELISA Kit
SpecificityThis assay recognizes both recombinant and natural Rat IL1R2.
ConjugateHRP
ShippingThis ELISA Kit is shipped at ambient temperature.
StorageUnopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA
Assay typeSolid Phase Sandwich ELISA (quantitative)
Sample typeSerum
Sensitivity4.7 pg/mL
Assay range15.63-1000 pg/mL
Materials provided1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution
Product overviewThis Rat IL1R2 ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Rat IL1R2 protein in Serum . It contains recombinant Rat IL1R2, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.
InterferencePreparations of rat IL1B and rat IL1LB at 50 ng/mL in a mid-range recombinant rat IL1R2 control were assayed for interference. No significant interference was observed.

Synonyms: Il-1r2 ELISA Kit, Rat; Il1r2 ELISA Kit, Rat; Il1rb ELISA Kit, Rat

Image / Experimental Information

Image 1 DescriptionThis standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Image 1 Alt TextRat IL-1R2/CD121b ELISA Kit Standard Curve 143
Image 1 URLSource image
Image 2 DescriptionThis standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Image 2 Alt TextRat IL-1R2/CD121b ELISA Kit Specificity 165
Image 2 URLSource image

Background Information

Full Nameinterleukin 1 receptor, type II
DescriptionInterleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. The pleiotropic cytokine IL1 is produced to regulate the development and maintenance of the inflammatory responses and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors that can bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signaling, whereas the IL-1R2/CD121b has no signaling property and acts as a decoy for IL-1. IL-1R2/CD121b structurally consisting of a ligand-binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes, and endothelial cells. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine.
Research Areas
  • Neuroinflammation
References
  1. Cannon JG, et al . (1997) Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome. J Clin Immunol. 17 (3): 253-61.
  2. Liu C, et al . (1996) Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. J Biol Chem. 271 (34): 20965-72.
  3. Van der Poll T, et al . (1997) Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. J Infect Dis. 175 (1): 118-22.

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