| Catalog No. | Size | Price (USD) |
| 13133-MM05-A-25 | 25 Tests | $103.68 |
| 13133-MM05-A-100 | 100 Tests | $325.84 |
General Information
| Product name | Anti-Tissue Factor Antibody (APC), Mouse Monoclonal |
| Validated applications | FCM (FAQ Protocol) |
| Species reactivity | Reacts with: Human |
| Specificity | Human Tissue Factor |
| Immunogen | Recombinant Human F3 / Tissue factor / CD142 protein (Catalog#13133-H08H) |
| Preparation | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human F3 / Tissue factor / CD142 (rh F3 / Tissue factor / CD142; Catalog#13133-H08H; P13726; Met 1-Glu 251) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Source | Monoclonal Mouse IgG2a Clone #05 |
| Purification | Protein A |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Concentration | 1 μl/Test, 0.1 mg/ml |
| Conjugate | APC |
| Form | Liquid |
| Shipping | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! |
Synonyms: Anti-CD142 Antibody; Anti-TF Antibody; Anti-TFA Antibody
Image / Experimental Information
| Image 1 Description | Flow cytometric analysis of F3 (CD142) expression on human A431 cells. |
| Image 1 Alt Text | Human Coagulation Factor III / Tissue Factor / CD142 Flow Cytometry (FC) 5365 |
| Image 1 URL | Source image |
Background Information
| Full Name | coagulation factor III (thromboplastin, tissue factor) |
| Description | Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating, the plasma serine protease, factor VIIa, following vascular injury. Tissue factor is not only the main physiological initiator of normal blood coagulation, but is also important in the natural history of solid malignancies in that it potentiates metastasis and angiogenesis and mediates outside-in signalling. Tissue factor is expressed constitutively by many tissues which are not in contact with blood and by other cells upon injury or activation; the latter include endothelial cells, tissue macrophages, and peripheral blood monocytes. Coagulation Factor III is a transmembrane glycoprotein that localizes the coagulation serine protease factor VII/VIIa (FVII/VIIa) to the cell surface. The primary function of TF is to activate the clotting cascade. The TF:FVIIa complex also activates cells by cleavage of a G-protein coupled receptor called protease-activated receptor 2 (PAR2). TF is expressed by tumor cells and contributes to a variety of pathologic processes, such as thrombosis, metastasis, tumor growth, and tumor angiogenesis. As a key regulator of haemostasis and angiogenesis, it is also involved in the pathology of several diseases, including cardiovascular, inflammatory and neoplastic conditions. |
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