Mouse IFN gamma ELISA Kit sinobiological KIT50709

$400.00
In stock
SKU
KIT50709
Catalog No.SizePrice (USD)
KIT50709-11 Kit (96 Tests)$414.71
KIT50709-55 Kit (96 Tests)$1,747.71
KIT50709-4848 Tests$266.60

General Information

Product nameMouse IFN gamma ELISA Kit
SpecificityThis assay recognizes both recombinant and natural Mouse IFN gamma.
ConjugateHRP
ShippingThis ELISA Kit is shipped at ambient temperature.
StorageUnopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA
Assay typeSolid Phase Sandwich ELISA (quantitative)
Sample typeCell supernatant
Sensitivity8.04 pg/mL
Assay range31.25-2000 pg/mL
Materials provided1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Standard Dissolution Buffer 7. Color Reagent A 8. Color Reagent B 9. Stop Solution
Product overviewThis Mouse IFN gamma ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Mouse IFN gamma protein in Cell supernatant . It contains recombinant Mouse IFN gamma, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.

Synonyms: If2f ELISA Kit, Mouse; Ifg ELISA Kit, Mouse; IFN-g ELISA Kit, Mouse; Ifng ELISA Kit, Mouse

Image / Experimental Information

Image 1 DescriptionThis standard curve is only for demonstration purposes. A standard curve should be generated for each assay.
Image 1 Alt TextMouse IFN gamma ELISA Kit Standard Curve 42007
Image 1 URLSource image

Background Information

Full Nameinterferon, gamma
DescriptionIFN gamma, also known as IFNG, is a secreted protein that belongs to the type II interferon family. IFN gamma is produced predominantly by natural killer and natural killer T cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte effector T cells once antigen-specific immunity develops. IFN gamma has antiviral, immunoregulatory, and anti-tumor properties. IFNG, in addition to having antiviral activity, has important immunoregulatory functions, it is a potent activator of macrophages and has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. The IFNG monomer consists of a core of six α-helices and an extended unfolded sequence in the C-terminal region. IFN gamma is critical for innate and adaptive immunity against viral and intracellular bacterial infections and tumor control. Aberrant IFN gamma expression is associated with some autoinflammatory and autoimmune diseases. The importance of IFN gamma in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFNG also promotes NK cell activity.
Research Areas
  • Neuroinflammation
Related Pathways
  • IL12 signaling pathway
Tags
  • Cancer Immunotherapy
  • Immune Checkpoint
  • Immunotherapy
  • Targeted Therapy
References
  1. Gray P W, et al. (1982) Structure of the human immune interferon gene. Nature. 298: 859-63.
  2. Taya Y, et al. (1982) Cloning and structure of the human immune interferon-gamma chromosomal gene. EMBO J. 1: 953-8.
  3. Goshima N, et al. (2008) Human protein factory for converting the transcriptome into an in vitro-expressed proteome. Nomura N Nat Methods. 5: 1011-7.
  4. Thiel DJ, et al. (2000) Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex. Structure. 8 (9): 927-36.
  5. Naylor SL, et al. (1983) Human immune interferon gene is located on chromosome 12. J Exp Med. 157 (3): 1020-7.
  6. Schoenborn JR, et al. (2007) Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol. 96: 41-101.

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