Human Serpin A1/Alpha-1-antitrypsin ELISA Kit sinobiological KIT10306
$714.00
In stock
SKU
KIT10306
| Catalog No. | Size | Price (USD) |
| KIT10306-1 | 1 Kit (96 Tests) | $740.55 |
General Information
| Product name | Human Serpin A1/Alpha-1-antitrypsin ELISA Kit |
| Specificity | This assay recognizes both recombinant and natural Human SERPINA1. |
| Conjugate | HRP |
| Shipping | This ELISA Kit is shipped at ambient temperature. |
| Storage | Unopened Kit: Store at 2 - 8℃ Opened/Reconstituted Reagents: Please refer to CoA |
| Assay type | Solid Phase Sandwich ELISA (quantitative) |
| Sample type | Serum |
| Sensitivity | 3.16 pg/mL |
| Assay range | 62.5-4000 pg/mL |
| Materials provided | 1. 96 well microplate coated with Capture Antibody 2. Detection Antibody conjugated to HRP 3. Standards 4. Wash Buffer Concentrate 5. Dilution Buffer Concentrate 6. Color Reagent A 7. Color Reagent B 8. Stop Solution |
| Product overview | This Human Serpin A1/Alpha-1-antitrypsin ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative measurement of Human Serpin A1/Alpha-1-antitrypsin protein in Serum . It contains recombinant Human Serpin A1/Alpha-1-antitrypsin, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use. |
Synonyms: A1A ELISA Kit, Human; A1AT ELISA Kit, Human; AAT ELISA Kit, Human; alpha-1-antitrypsin ELISA Kit, Human; alpha1AT ELISA Kit, Human; nNIF ELISA Kit, Human; PI ELISA Kit, Human; PI1 ELISA Kit, Human; PRO0684 ELISA Kit, Human; PRO2209 ELISA Kit, Human; PRO2275 ELISA Kit, Human; SERPINA1 ELISA Kit, Human
Image / Experimental Information
| Image 1 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 1 Alt Text | Human SerpinA1 ELISA Kit Standard Curve 17209 |
| Image 1 URL | Source image |
| Image 2 Description | This standard curve is only for demonstration purposes. A standard curve should be generated for each assay. |
| Image 2 Alt Text | Human SerpinA1 ELISA Kit Specificity 17223 |
| Image 2 URL | Source image |
Background Information
| Full Name | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 |
| Description | SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antitrypsin is mainly produced in the liver and acts as an antiprotease. Its principal function is to inactivate neutrophil elastase, preventing tissue damage. SerpinA1 (alpha1-antitrypsin), an acute phase protein and the classical neutrophil elastase inhibitor, is localized within lipid rafts in primary human monocytes in vitro. Its association with monocytes is inhibited by cholesterol depleting/efflux-stimulating agents (nystatin, filipin, MbetaCD (methyl-beta-cyclodextrin) and oxidized low-density lipoprotein (oxLDL) and conversely, enhanced by free cholesterol. Furthermore, SerpinA1/monocyte association per se depletes lipid raft cholesterol as characterized by the activation of extracellular signal-regulated kinase 2, formation of cytosolic lipid droplets, and complete inhibition of oxLDL uptake by monocytes. Previous population studies have suggested that heterozygote status for the AAT gene (SerpinA1) is a risk factor for chronic rhinosinusitis with nasal polyposis (CRSwNP). Alpha-1 antitrypsin deficiency is a recently identified genetic disease that occurs almost as frequently as cystic fibrosis. It is caused by various mutations in the SerpinA1 gene, and has numerous clinical implications. Alpha-1 antitrypsin deficiency is an inherited disease affecting the lung and liver. In the liver, alpha-1 antitrypsin deficiency may manifest as benign neonatal hepatitis syndrome; a small percentage of adults develop liver fibrosis, with progression to cirrhosis and hepatocellular carcinoma. Its most important physiologic functions are the protection of pulmonary tissue from aggressive proteolytic enzymes and regulation of pulmonary immune processes. |
| References |
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